Autophagy dysregulation by mutant fused in sarcoma--implications for amyotrophic lateral sclerosis.

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Blocking autophagy enhances the apoptotic effect of 18β-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation.Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

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Autophagy dysregulation by mutant fused in sarcoma--implications for amyotrophic lateral sclerosis.

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http://www.wikidata.org/entity/Q42000879

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

@yue

2015年論文

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2015年論文

@zh-hk

2015年論文

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2015年論文

@zh-tw

2015年论文

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2015年论文

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2015年论文

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name

Autophagy dysregulation by mut ...... amyotrophic lateral sclerosis.

@en

Autophagy dysregulation by mut ...... amyotrophic lateral sclerosis.

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Item

label

Autophagy dysregulation by mut ...... amyotrophic lateral sclerosis.

@en

Autophagy dysregulation by mut ...... amyotrophic lateral sclerosis.

@nl

prefLabel

Autophagy dysregulation by mut ...... amyotrophic lateral sclerosis.

@en

Autophagy dysregulation by mut ...... amyotrophic lateral sclerosis.

@nl

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Autophagy dysregulation by mut ...... amyotrophic lateral sclerosis

@en

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K Y Soo

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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons

Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics.

Mutant superoxide dismutase 1 overexpression in NSC-34 cells: effect of trehalose on aggregation, TDP-43 localization and levels of co-expressed glycoproteins.

Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

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e1945

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scholarly article

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10.1038/CDDIS.2015.311

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Julie D Atkin

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2015-10-29T00:00:00Z

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283326198

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amyotrophic lateral sclerosis

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4632325

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Autophagy dysregulation by mutant fused in sarcoma--implications for amyotrophic lateral sclerosis.

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P2860

P2860

Autophagy dysregulation by mutant fused in sarcoma--implications for amyotrophic lateral sclerosis.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P478

P50

P577

P5875

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P478

P50

P577

P5875

P698

P921

P932