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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal traffickingThe Unfolded Protein Response and the Role of Protein Disulfide Isomerase in NeurodegenerationMolecular motor proteins and amyotrophic lateral sclerosisRedox regulation in amyotrophic lateral sclerosisALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formationEndoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosisMutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assemblyImpaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosisA novel amyotrophic lateral sclerosis mutation in OPTN induces ER stress and Golgi fragmentation in vitro.Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumPhosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis.Novel roles for protein disulphide isomerase in disease states: a double edged sword?C9ORF72 expression and cellular localization over mouse development.Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences.ER stress and UPR in familial amyotrophic lateral sclerosis.Recombinant human antibodies: linkage of an Fab fragment from a combinatorial library to an Fc fragment for expression in mammalian cell culture.CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia.NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation.ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.Multifaceted deaths orchestrated by mitochondria in neurones.Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis.The role of s-nitrosylation and s-glutathionylation of protein disulphide isomerase in protein misfolding and neurodegeneration.Protein Folding Alterations in Amyotrophic Lateral Sclerosis.Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS.Protein Disulphide Isomerases: emerging roles of PDI and ERp57 in the nervous system and as therapeutic targets for ALS.Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase.Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis.Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells.Autophagy dysregulation by mutant fused in sarcoma--implications for amyotrophic lateral sclerosis.SOD1 Mutations Causing Familial Amyotrophic Lateral Sclerosis Induce Toxicity in Astrocytes: Evidence for Bystander Effects in a Continuum of Astrogliosis.Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex.Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.Properties of slow- and fast-twitch muscle fibres in a mouse model of amyotrophic lateral sclerosis.Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1.C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
P50
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P50
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հետազոտող
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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Julie D Atkin
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