Systematic mutational analysis of the active-site threonine of HIV-1 proteinase: rethinking the "fireman's grip" hypothesis.
about
Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursorEffect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 ProteaseNinety-Nine Is Not Enough: Molecular Characterization of Inhibitor-Resistant Human Immunodeficiency Virus Type 1 Protease Mutants with Insertions in the Flap RegionEnzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavirEvidence that the Bacillus subtilis SpoIIGA protein is a novel type of signal-transducing aspartic proteaseInhibitor and substrate binding induced stability of HIV-1 protease against sequential dissociation and unfolding revealed by high pressure spectroscopy and kineticsDimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacityKinetics of the dimerization of retroviral proteases: the "fireman's grip" and dimerization.Proteinases of betaretroviruses bind single-stranded nucleic acids through a novel interaction module, the G-patch.Importance of the N terminus of rous sarcoma virus protease for structure and enzymatic function.Design of a trans protease lentiviral packaging system that produces high titer virus.Folded monomer of HIV-1 protease.Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties.GRL-079, a novel P2-Tp-THF-C5-alkylamine- and P2' -Abt-containing HIV-1 protease inhibitor, is extremely potent against multi-drug-resistant HIV-1 variants including HIVDRVRp51 and has a high genetic barrier against the emergence of resistant varian
P2860
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P2860
Systematic mutational analysis of the active-site threonine of HIV-1 proteinase: rethinking the "fireman's grip" hypothesis.
description
2000 nî lūn-bûn
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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name
Systematic mutational analysis ...... e "fireman's grip" hypothesis.
@en
Systematic mutational analysis ...... e "fireman's grip" hypothesis.
@nl
type
label
Systematic mutational analysis ...... e "fireman's grip" hypothesis.
@en
Systematic mutational analysis ...... e "fireman's grip" hypothesis.
@nl
prefLabel
Systematic mutational analysis ...... e "fireman's grip" hypothesis.
@en
Systematic mutational analysis ...... e "fireman's grip" hypothesis.
@nl
P2093
P2860
P356
P1433
P1476
Systematic mutational analysis ...... e "fireman's grip" hypothesis.
@en
P2093
Konvalinka J
Kräusslich HG
Strisovsky K
P2860
P304
P356
10.1110/PS.9.9.1631
P577
2000-09-01T00:00:00Z