Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. - Wikidata - awgldk - TriplyDB

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

http://www.wikidata.org/entity/Q42076186

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CSIG inhibits PTEN translation in replicative senescence Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization Nuclear PI3K signaling in cell growth and tumorigenesis The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy Nuclear PTEN levels and G2 progression in melanoma cells PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs Decrease in PTEN and increase in Akt expression and neuron size in aged rat spinal cord.Pten regulates development and lactation in the mammary glands of dairy cows.AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor Autophagy regulation in cancer development and therapy.Phosphatase and tensin homolog on chromosome 10 is phosphorylated in primary effusion lymphoma and Kaposi's sarcoma.Prognostic significance of PTEN, Ki-67 and CD44s expression patterns in gastrointestinal stromal tumors PTEN regulates PDGF ligand switch for β-PDGFR signaling in prostate cancer PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).A Novel Mechanism of PPARgamma Regulation of TGFbeta1: Implication in Cancer Biology ATP modulates PTEN subcellular localization in multiple cancer cell lines.The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomes Portrait of PTEN: messages from mutant mice.Antitumor activity of NVP-BKM120--a selective pan class I PI3 kinase inhibitor showed differential forms of cell death based on p53 status of glioma cells Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.PTEN: a new guardian of the genome.A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.Horizon scanning for novel therapeutics for the treatment of prostate cancer.PTEN in DNA damage repair.Is Cytoplasmic PTEN a Specific Target for Neuronal Survival?Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interaction.Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation.Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb.Semaphorin 3A upregulates FOXO 3a-dependent MelCAM expression leading to attenuation of breast tumor growth and angiogenesis.ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization.Autophagic homeostasis is required for the pluripotency of cancer stem cells.Cell Cycle Control by PTEN.Thalidomide decreases gelatinase production by malignant B lymphoid cell lines through disruption of multiple integrin-mediated signaling pathways.MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells.Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo.The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.

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Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

http://www.wikidata.org/entity/Q42076186

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

@zh-hant

name

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

@en

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

@nl

type

label

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

@en

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

@nl

prefLabel

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

@en

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

@nl

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MCB.25.14.6211-6224.2005

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Molecular and Cellular Biology

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Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.

@en

P2093

Gary E Gallick

http://www.w3.org/2001/XMLSchema#string

Juinn-Lin Liu

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W K Alfred Yung

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Xiaoyang Sheng

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Zhenyu Mao

http://www.w3.org/2001/XMLSchema#string

Zsuzsanna K Hortobagyi

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P2860

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y

Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

Protean PTEN: form and function

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors

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6211-6224

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10.1128/MCB.25.14.6211-6224.2005

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1168816

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