Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure
about
Insulin resistance, hyperglycemia, and atherosclerosisStability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and diseaseNa+-sensitive elevation in blood pressure is ENaC independent in diet-induced obesity and insulin resistanceCeacam1 deletion causes vascular alterations in large vesselsSerine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cellsRegulation of obesity and insulin resistance by nitric oxideInsulin Signaling and Heart Failure.Modification of high saturated fat diet with n-3 polyunsaturated fat improves glucose intolerance and vascular dysfunctionAngiotensin II stimulates thick ascending limb NO production via AT(2) receptors and Akt1-dependent nitric-oxide synthase 3 (NOS3) activationMouse models of the metabolic syndrome.Physical activity maintains aortic endothelium-dependent relaxation in the obese type 2 diabetic OLETF ratPartial deletion of eNOS gene causes hyperinsulinemic state, unbalance of cardiac insulin signaling pathways and coronary dysfunction independently of high fat diet.Serum from calorie-restricted rats activates vascular cell eNOS through enhanced insulin signaling mediated by adiponectin.Regulation of nitric oxide production in health and disease.Metabolomic analyses for atherosclerosis, diabetes, and obesity.Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide.Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null miceKnockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overloadRole of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury.Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.Antiobesogenic role of endothelial nitric oxide synthase.Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice.Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complexCeramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo.Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes.Mechanisms of lipotoxicity in the cardiovascular system.MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue.Impact of age on the vasodilatory function of human skeletal muscle feed arteriesSIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity.Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertensionInsulin resistance: metabolic mechanisms and consequences in the heart.Opportunity "nox": a novel approach to preventing endothelial dysfunction in the context of insulin resistance.Sphingolipid metabolism and obesity-induced inflammation.Exercise training improves vascular mitochondrial function.A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance.Hypertension and decreased aortic compliance due to reduced elastin amounts do not increase atherosclerotic plaque accumulation in Ldlr-/- mice.Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome.Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations
P2860
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P2860
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Contribution of insulin and Ak ...... al function and blood pressure
@en
Contribution of insulin and Ak ...... al function and blood pressure
@nl
type
label
Contribution of insulin and Ak ...... al function and blood pressure
@en
Contribution of insulin and Ak ...... al function and blood pressure
@nl
prefLabel
Contribution of insulin and Ak ...... al function and blood pressure
@en
Contribution of insulin and Ak ...... al function and blood pressure
@nl
P2093
P2860
P50
P1433
P1476
Contribution of insulin and Ak ...... al function and blood pressure
@en
P2093
Christian Riehle
Deborah Jones
Derrick Gale
Elaine Hillas
J David Symons
Jason Tanner
Lloyd J Wilson
Milda Palionyte
Robert C Cooksey
Shawna L McMillin
P2860
P304
P356
10.1161/CIRCRESAHA.108.189316
P577
2009-04-02T00:00:00Z