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Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's DiseaseThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseTen years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinicThe BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohortA visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via ExosomesIncreased DJ-1 in urine exosome of Korean males with Parkinson's disease.Cerebrospinal fluid extracellular vesicles undergo age dependent declines and contain known and novel non-coding RNAs.Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury.Transcellular spreading of huntingtin aggregates in the Drosophila brain.Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers.Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting.Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organsExosomes, an Unmasked Culprit in Neurodegenerative Diseases.Neuroprotective function of 14-3-3 proteins in neurodegenerationStructural biology of the LRRK2 GTPase and kinase domains: implications for regulation.Genetic, structural, and molecular insights into the function of ras of complex proteins domains.Use and isolation of urinary exosomes as biomarkers for diabetic nephropathy.Mass spectrometry of extracellular vesicles.The secret life of extracellular vesicles in metal homeostasis and neurodegeneration.Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathologyExosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets.Neurovesicles in Brain Development.Extracellular vesicles and intercellular communication within the nervous system.14-3-3 and β-catenin are secreted on extracellular vesicles to activate the oncogenic Wnt pathway.Exosomes in Parkinson's Disease.Proteomic profile of maternal-aged blastocoel fluid suggests a novel role for ubiquitin system in blastocyst quality.Exosomes and their Application in Biomedical Field: Difficulties and Advantages.Peptidylarginine Deiminases-Roles in Cancer and Neurodegeneration and Possible Avenues for Therapeutic Intervention via Modulation of Exosome and Microvesicle (EMV) Release?Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease.Nanoparticle suspensions enclosed in methylcellulose: a new approach for quantifying nanoparticles in transmission electron microscopy.LRRK2 Promotes Tau Accumulation, Aggregation and Release.The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.LRRK2 dephosphorylation increases its ubiquitination.Polymer brain-nanotherapeutics for multipronged inhibition of microglial α-synuclein aggregation, activation, and neurotoxicity.Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers.A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson's Disease.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
LRRK2 secretion in exosomes is regulated by 14-3-3.
@en
LRRK2 secretion in exosomes is regulated by 14-3-3.
@nl
type
label
LRRK2 secretion in exosomes is regulated by 14-3-3.
@en
LRRK2 secretion in exosomes is regulated by 14-3-3.
@nl
prefLabel
LRRK2 secretion in exosomes is regulated by 14-3-3.
@en
LRRK2 secretion in exosomes is regulated by 14-3-3.
@nl
P2093
P2860
P50
P356
P1476
LRRK2 secretion in exosomes is regulated by 14-3-3.
@en
P2093
Carrie A Stewart
Darren J Moore
Dongquan Chen
Gene P Siegal
James A Mobley
Jeri Y Williams
João P L Daher
Kyle B Fraser
Kyoko Kojima
Philip J Webber
P2860
P304
P356
10.1093/HMG/DDT346
P577
2013-07-25T00:00:00Z