P21-activated kinase is required for mitotic progression and regulates Plk1.
about
Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle AssemblyCritical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodelingNeurofibromatosis type 2 protein, NF2: an uncoventional cell cycle regulator.Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinementRhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damagePAK signalling during the development and progression of cancerThe Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.Knowledge based identification of essential signaling from genome-scale siRNA experiments.Purification and proteomic identification of putative upstream regulators of polo-like kinase-1 from mitotic cell extracts.p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells.Serine-71 phosphorylation of Rac1 modulates downstream signaling.PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop.PAK1 as a therapeutic target.Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma.Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver agingRho GTPase-independent regulation of mitotic progression by the RhoGEF Net1Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cellsPak protein kinases and their role in cancer.PAK signaling in oncogenesis.The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets.Development of small-molecule inhibitors of the group I p21-activated kinases, emerging therapeutic targets in cancer.Untangling the complexity of PAK1 dynamics: The future challenge.PAK signaling in cancer.p21-Activated protein kinases and their emerging roles in glucose homeostasis.P21 activated kinases: structure, regulation, and functions.Understanding the Polo Kinase machine.Bioinformatics exploration of PAK1 (P21-activated kinase-1) revealed potential network gene elements in breast invasive carcinoma.Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning.Structure, biochemistry, and biology of PAK kinases.Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins.Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation.Identification and functional characterization of polo-like kinase 2 autoregulatory sitesRac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.p21-activated kinase 4 regulates mitotic spindle positioning and orientation.Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry.PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression.
P2860
Q26771374-7BBAB0D8-664D-4440-B959-70088AD30063Q26777713-B3EDA6CC-8E29-44B7-A0B4-BE6104ACDC71Q26825296-204414DF-480E-4DFB-BC89-708758DF712DQ28255939-3991946E-595F-49BF-98F2-11BAA6A3BD6BQ28274939-A8DE8DAE-3D5F-44B2-A03B-E04A20A7C687Q28307460-506DBA9B-3BAF-4DCF-940B-E91BAB728838Q30538230-7FC2D24A-C522-453B-9BB5-38DFB01C8B8AQ30656511-A5AA5F31-0991-4479-A055-C9C72EE1451AQ33490280-D5CB9EAF-8249-454B-8A4E-278DE65CA907Q33703090-D1C6F366-D908-4CF7-AA6F-E313DD07CBBDQ33745071-1077BC7D-1AA6-4C55-A7CC-F60B1487578AQ34160731-C86CD4A3-A018-419B-AAAE-0C4777AB0F61Q34412353-A57F3B30-FA3F-46B5-AF99-DFCFDA1A3238Q34723518-53654DC8-9252-4B8C-AA57-C7561A78C3FAQ35108164-330670FB-0284-4BEE-8E69-25F0FDEE6727Q35287780-96B475FF-EB0B-4533-B96F-3B50D774EA3AQ35987724-DD39E2F4-56D4-49F6-87FF-E556F2109589Q36733195-C4F4344F-39BD-4417-84DD-BE1C75088A07Q37131476-8353CC05-6626-4686-8115-0A922DA9F7FEQ37254703-B48AAAFD-CC2E-4387-8151-958D6FE95AEEQ37376062-85E4C622-548D-4BDB-A313-1D37625C301CQ37494233-57CA913B-2655-497D-BAE8-8A202FE9E18EQ37606940-1D536A04-A839-45B6-A9A6-CC527DBA240AQ37715015-6D52E9A2-487A-4D13-9625-0306997B0D19Q38057750-FE58C944-0958-4B8C-97CE-FE1F9643DEFAQ38060732-0E6D7318-0FC7-48ED-A46D-D595E33BE86FQ38173847-DF8A1602-E184-45FE-AA28-CC80ABF0A006Q38198494-05487377-A7A0-467C-A968-0A489F69AF32Q38331761-E3C5A8AF-EC8C-4267-8493-703559E46C49Q38444442-AD80685E-0427-4660-825B-18E38DE27788Q38676643-3DD8CD5F-22D0-44F6-A2EA-6844C0F91A77Q38779105-B1D943C8-3DB8-4D6E-8242-972CF783A1E2Q39003157-7F333973-716C-4501-BA68-53AE2314E0B5Q39159284-D58B1EB9-7D65-412C-A680-F5AC7B5D1E2FQ39410909-BB11ABA1-D6F9-4696-8169-B842C200F676Q40748186-DFCFCFCE-AE9C-400B-AD9A-1BF212C5B004Q41629566-EC4CEC83-8AEF-4B34-8533-8B7595372108Q42143266-EAB0B647-087E-4B32-927E-9023504A1C62Q42749968-A5AB8994-DDE0-4806-95F3-E72C3D4AC5F6Q42813699-5394949E-5B11-472D-9B79-7D785AE5AE9F
P2860
P21-activated kinase is required for mitotic progression and regulates Plk1.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
P21-activated kinase is required for mitotic progression and regulates Plk1.
@en
P21-activated kinase is required for mitotic progression and regulates Plk1.
@nl
type
label
P21-activated kinase is required for mitotic progression and regulates Plk1.
@en
P21-activated kinase is required for mitotic progression and regulates Plk1.
@nl
prefLabel
P21-activated kinase is required for mitotic progression and regulates Plk1.
@en
P21-activated kinase is required for mitotic progression and regulates Plk1.
@nl
P2093
P356
P1433
P1476
P21-activated kinase is required for mitotic progression and regulates Plk1
@en
P2093
A Schnelzer
K von Lohneysen
P2860
P2888
P304
P356
10.1038/ONC.2008.131
P407
P50
P577
2008-04-21T00:00:00Z
P5875
P6179
1019291363