c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. - Wikidata - awgldk - TriplyDB

c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

http://www.wikidata.org/entity/Q42174623

about

GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis Identification and characterization of Hoxa9 binding sites in hematopoietic cells Rare Cytogenetic Abnormalities and Alteration of microRNAs in Acute Myeloid Leukemia and Response to Therapy Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.Prepaying the entropic cost for allosteric regulation in KIX Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.Molecular recognition by the KIX domain and its role in gene regulation.C/EBPα and MYB regulate FLT3 expression in AML Mapping of MN1 sequences necessary for myeloid transformation.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia.MLL fusions: pathways to leukemia CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL.Cell cycle control in acute myeloid leukemia.Myb overexpression overrides androgen depletion-induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration resistance.PBX3 is an important cofactor of HOXA9 in leukemogenesis.Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells Gfi1 integrates progenitor versus granulocytic transcriptional programming.Epigenetic roles of MLL oncoproteins are dependent on NF-κB In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9.Distal regulation of c-myb expression during IL-6-induced differentiation in murine myeloid progenitor M1 cells.Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.BCOR regulates myeloid cell proliferation and differentiation.The molecular biology of mixed lineage leukemia.Molecular pathology of mixed-lineage leukemia.Myb expression is critical for myeloid leukemia development induced by Setbp1 activation.Gfi1-cells and circuits: unraveling transcriptional networks of development and disease Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia.Role and potential for therapeutic targeting of MYB in leukemia.The role of HOX genes in normal hematopoiesis and acute leukemia.Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.

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c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

http://www.wikidata.org/entity/Q42174623

description

2006 nî lūn-bûn

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name

c-Myb is an essential downstre ...... mation of hematopoietic cells.

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c-Myb is an essential downstre ...... mation of hematopoietic cells.

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c-Myb is an essential downstre ...... mation of hematopoietic cells.

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c-Myb is an essential downstre ...... mation of hematopoietic cells.

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c-Myb is an essential downstre ...... rmation of hematopoietic cells

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Arndt Borkhardt

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Claudia B Bittner

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Deniz T Zeisig

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Jay L Hess

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Jon Frampton

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Robert K Slany

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Uta Fuchs

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P2860

HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins

Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells

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1

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16507773

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