Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells.
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Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)Regulating the immune system via IL-15 transpresentationInsights into cytokine-receptor interactions from cytokine engineeringCrystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in transThe shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapyHuman natural killer cell development in secondary lymphoid tissuesPlasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection.Evidence of STAT5-dependent and -independent routes to CD8 memory formation and a preferential role for IL-7 over IL-15 in STAT5 activationCombined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo.IL-15: a central regulator of celiac disease immunopathology.Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cellsDifferential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types.High dose of plasmid IL-15 inhibits immune responses in an influenza non-human primates immunogenicity modelCD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cisConverting IL-15 to a superagonist by binding to soluble IL-15R{alpha}Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.MHC class I and TCR avidity control the CD8 T cell response to IL-15/IL-15Rα complex.The IL-15/IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cellsSelective dependence of H2-M3-restricted CD8 responses on IL-15IL-15, in synergy with RAE-1ɛ, stimulates TCR-independent proliferation and activation of CD8(+) T cells.Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum.Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype.Role of interleukin-7 in bone and T-cell homeostasis.Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasisParacrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Rα in human monocytes and dendritic cellsDevelopment, trafficking, and function of memory T-cell subsets.Latent virus influences the generation and maintenance of CD8+ T cell memory.IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation.Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion.Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentationEpidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivoCutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infectionIFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activityFunctions of γC cytokines in immune homeostasis: current and potential clinical applications.Trans-presentation: a novel mechanism regulating IL-15 delivery and responses.Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression.
P2860
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P2860
Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Transregulation of memory CD8 ...... ha+ bone marrow-derived cells.
@en
Transregulation of memory CD8 ...... ha+ bone marrow-derived cells.
@nl
type
label
Transregulation of memory CD8 ...... ha+ bone marrow-derived cells.
@en
Transregulation of memory CD8 ...... ha+ bone marrow-derived cells.
@nl
prefLabel
Transregulation of memory CD8 ...... ha+ bone marrow-derived cells.
@en
Transregulation of memory CD8 ...... ha+ bone marrow-derived cells.
@nl
P2093
P1433
P1476
Transregulation of memory CD8 ...... ha+ bone marrow-derived cells.
@en
P2093
Kimberly D Klonowski
Kimberly S Schluns
Leo Lefrançois
P304
P356
10.1182/BLOOD-2003-08-2814
P407
P577
2003-09-25T00:00:00Z