about
Myosin 1b promotes the formation of post-Golgi carriers by regulating actin assembly and membrane remodelling at the trans-Golgi networkAP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesisFunctions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomesBLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organellesMyosin Ib modulates the morphology and the protein transport within multi-vesicular sorting endosomesEarly/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoformARF6 controls post-endocytic recycling through its downstream exocyst complex effectorBLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomesInactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentationCell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes.Inhibition of retrograde transport protects mice from lethal ricin challenge.Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenicClathrin adaptor epsinR is required for retrograde sorting on early endosomal membranes.Shiga toxin induces tubular membrane invaginations for its uptake into cells.Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes.ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane.
P50
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P50
name
Danièle Tenza
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Danièle Tenza
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Danièle Tenza
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type
label
Danièle Tenza
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Danièle Tenza
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Danièle Tenza
@nl
prefLabel
Danièle Tenza
@ast
Danièle Tenza
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Danièle Tenza
@nl