Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17
about
A missense mutation in PMEL17 is associated with the Silver coat color in the horseThe ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and compositionLocalization to mature melanosomes by virtue of cytoplasmic dileucine motifs is required for human OCA2 functionBLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organellesThe tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesisMelanosomes--dark organelles enlighten endosomal membrane transportBLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery.PMEL Amyloid Fibril Formation: The Bright Steps of PigmentationInactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentationMHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes.Electron tomography of early melanosomes: implications for melanogenesis and the generation of fibrillar amyloid sheets.The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Iron upregulates melanogenesis in cultured retinal pigment epithelial cellsProprotein convertases process Pmel17 during secretion.The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motif.Mechanisms of protein delivery to melanosomes in pigment cells.Toward a systems biology of mouse inner ear organogenesis: gene expression pathways, patterns and network analysis.The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma.Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.The Apaf-1-binding protein Aven is cleaved by Cathepsin D to unleash its anti-apoptotic potentialThe Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes.PMEL: a pigment cell-specific model for functional amyloid formationLysosome-related organelles: driving post-Golgi compartments into specialisation.Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane.A mutation within the transmembrane domain of melanosomal protein Silver (Pmel17) changes lumenal fragment interactions.Ocular Albinism Type 1 Regulates Melanogenesis in Mouse Melanocytes.Gpnmb is a melanosome-associated glycoprotein that contributes to melanocyte/keratinocyte adhesion in a RGD-dependent fashion.N-terminal domains elicit formation of functional Pmel17 amyloid fibrilsCell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.Hypopigmentation in Hermansky-Pudlak syndrome.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis.Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL expression.Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2.
P2860
Q21283788-66EE0DF7-9756-4CD6-8FF5-45E8E7D1E026Q24311263-89C96999-2BBD-4B9D-9A0D-AA1977B98ED1Q24312002-B338B29B-1276-4DF8-BC9C-31435A0521A7Q24337651-3D884929-D179-47DB-8655-48CED80E70F1Q24338990-5137C8CD-B5C7-4F2E-95B0-AE2E90930988Q24647195-C2A3EFC6-E888-481E-AB88-49FAAA9F5478Q27310758-1C7C1D98-EFE5-451B-8222-35C4C336C499Q28076932-2B6EFBC8-8A5F-4119-88DF-5769FD62955CQ28585331-EEFCFA4B-15AE-40D2-94D3-D1E5B5819B19Q30437794-DA18176D-2144-4D9E-957F-161418584D27Q30485074-FF62F17F-6233-4CC6-B26D-956403021375Q33694588-3A273D85-179E-4C96-9C13-2D4FFA4EF8F9Q33855252-7B4212CB-94E5-47F0-A88A-51E60541D792Q33862796-B67806A4-EEC1-4244-AD1A-64D100A016D4Q34616094-2B79DD1F-F354-474D-8E56-F77CF0EAF6B8Q34685446-8051BC51-08C4-4EE2-8675-8D3790AB5DF0Q35000777-1142F774-3187-44FF-B732-2BE6BC5589B9Q35936316-241654ED-52FD-4E42-9ABF-795B9643A6E0Q36052331-54858BF5-ABEF-478B-BAC5-6FF6FA02A1C3Q36097890-2CF20005-246D-4C7E-925F-EF5A04E6568AQ36161681-04FE41BA-730F-41DF-B99A-FE5F1B96ADABQ36174027-8079F093-14B4-4278-88A0-9A4C8A798970Q36574029-A605394C-165F-4ED9-B64E-35355E23DCFAQ36726485-9B4DC6AD-7243-4A20-AE9B-D5B0473211F7Q36788313-2E0F9936-BD34-4E78-B158-FC5712B29449Q36880252-C231188E-2864-4D76-A780-DD16D1C5AED7Q36884589-1700F04C-C29F-407B-A623-7FDC22879F04Q36961713-23A9BFD7-F132-4E2C-BD8C-388055117FC9Q36967843-59E7EB6F-3AE0-40F7-814E-3D216912955DQ37354349-27C3C740-BBAC-4356-A46D-78380E857AD2Q37357717-7FBA59B3-3EE6-46AA-9534-22BA28A94D00Q37377153-9A50BDCE-78F4-445B-A4BE-E6670F357477Q37413798-3CAC8386-608F-42B7-BAEA-ADCF0CD39021Q37467613-C1EB8EE0-FAAE-4134-AB9C-A9BEF4D102CDQ38068089-8753EDBC-B793-48B6-9B71-4DED6762187FQ38106424-9F93978B-22FB-49A9-9037-FA6E1425A7BDQ38777380-DFCF103F-1571-4B22-A2E7-E76F37D75DA6Q38965381-42F75F84-8A3B-476E-A0AA-D9B4C95EA6DBQ39013582-59C20C37-1924-4F40-8563-78F66368FCBAQ39252421-9B9FB625-EF23-4F35-8B7C-51E70FEAEED7
P2860
Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Dual loss of ER export and end ...... the silver mutation of Pmel17
@ast
Dual loss of ER export and end ...... the silver mutation of Pmel17
@en
Dual loss of ER export and end ...... the silver mutation of Pmel17
@nl
type
label
Dual loss of ER export and end ...... the silver mutation of Pmel17
@ast
Dual loss of ER export and end ...... the silver mutation of Pmel17
@en
Dual loss of ER export and end ...... the silver mutation of Pmel17
@nl
prefLabel
Dual loss of ER export and end ...... the silver mutation of Pmel17
@ast
Dual loss of ER export and end ...... the silver mutation of Pmel17
@en
Dual loss of ER export and end ...... the silver mutation of Pmel17
@nl
P2093
P2860
P50
P356
P1476
Dual loss of ER export and end ...... the silver mutation of Pmel17
@en
P2093
Alexander C Theos
Dawn C Harper
Elena V Sviderskaya
Graça Raposo
Joanne F Berson
Kathryn E Herman
M Lynn Lamoreux
Sarah C Theos
P2860
P304
P356
10.1091/MBC.E06-01-0081
P577
2006-06-07T00:00:00Z