Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.
about
The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors3D domain swapping: a mechanism for oligomer assemblyCloning and characterization of deer mouse (Peromyscus maniculatus) cytokine and chemokine cDNAsStructure of the active core of human stem cell factor and analysis of binding to its receptor KitRefined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factorManipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokinesMutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition.Inter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinantThreading analysis suggests that the obese gene product may be a helical cytokine.Site-specific PEGylation of engineered cysteine analogues of recombinant human granulocyte-macrophage colony-stimulating factor.A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor.The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling.Domain swapping: entangling alliances between proteins.Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement.Specific human granulocyte-macrophage colony-stimulating factor antagonists.Overview of the purification of recombinant proteins.Delivery of GM-CSF to Protect against Influenza Pneumonia.Proposed three-dimensional structure for the cellular prion proteinMonomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for functionHematopoietic cytokines: similarities and differences in the structures, with implications for receptor binding.Role of the C-terminus in the activity, conformation, and stability of interleukin-6.Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor binding.Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure.Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognitionRecombinant antibodies in bioactive peptide design.Design, synthesis and conformational analysis of hGM-CSF(13-31)-Gly-Pro-Gly-(103-116).Conformation of four peptides corresponding to the alpha-helical segments of human GM-CSF.Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transductionGeneration of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands.Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3Rational design of granulocyte-macrophage colony-stimulating factor antagonist peptides.Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites.Identification of key charged residues of human interleukin-5 in receptor binding and cellular activation.Homodimeric murine interleukin-3 agonists indicate that ligand dimerization is important for high-affinity receptor complex formation.Three-dimensional crystal structure of recombinant murine interferon-beta.Cells transfected with human interleukin 6 cDNA acquire binding sites for the hepatitis B virus envelope proteinReceptor binding properties of four-helix-bundle growth factors deduced from electrostatic analysis.Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting.
P2860
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P2860
Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Novel fold and putative recept ...... age colony-stimulating factor.
@en
Novel fold and putative recept ...... age colony-stimulating factor.
@nl
type
label
Novel fold and putative recept ...... age colony-stimulating factor.
@en
Novel fold and putative recept ...... age colony-stimulating factor.
@nl
prefLabel
Novel fold and putative recept ...... age colony-stimulating factor.
@en
Novel fold and putative recept ...... age colony-stimulating factor.
@nl
P356
P1433
P1476
Novel fold and putative recept ...... hage colony-stimulating factor
@en
P2093
P304
P356
10.1126/SCIENCE.1837174
P407
P50
P577
1991-12-01T00:00:00Z