about
An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathwayIdentification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanismsTrapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysisThe crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agentsUnderstanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpartA new subclass of the zinc metalloproteases superfamily revealed by the solution structure of peptide deformylaseSolution structure of nickel-peptide deformylaseComparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation featuresNew antibiotic molecules: bypassing the membrane barrier of gram negative bacteria increases the activity of peptide deformylase inhibitorsN-myristoylation regulates the SnRK1 pathway in Arabidopsis.Peptide deformylase of eukaryotic protists: a target for new antiparasitic agents?Comparative metagenomics of microbial traits within oceanic viral communitiesControl of protein life-span by N-terminal methionine excisionThe crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms.Organellar peptide deformylases: universality of the N-terminal methionine cleavage mechanism.Impact of the N-terminal amino acid on targeted protein degradation.In vivo deuteration of transfer RNAs: overexpression and large-scale purification of deuterated specific tRNAs.Role of the 1-72 base pair in tRNAs for the activity of Escherichia coli peptidyl-tRNA hydrolase.Methionyl-tRNA synthetase from Bacillus stearothermophilus: structural and functional identities with the Escherichia coli enzyme.Protein N-terminal methionine excision.Involvement of the size and sequence of the anticodon loop in tRNA recognition by mammalian and E. coli methionyl-tRNA synthetases.Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in ArabidopsisEnCOUNTer: a parsing tool to uncover the mature N-terminus of organelle-targeted proteins in complex samplesMolecular identification and functional characterization of the first Nα-acetyltransferase in plastids by global acetylome profiling.Tools for analyzing and predicting N-terminal protein modifications.Expanded impact of protein N-myristoylation in plantsMutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.Protein lipidation meets proteomics.A unique peptide deformylase platform to rationally design and challenge novel active compounds.Cotranslational processing mechanisms: towards a dynamic 3D model.MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.N-terminal protein modifications: Bringing back into play the ribosome.Proteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition.Rice peptide deformylase PDF1B is crucial for development of chloroplasts.The intriguing realm of protein biogenesis: Facing the green co-translational protein maturation networks.SILProNAQ: A Convenient Approach for Proteome-Wide Analysis of Protein N-Termini and N-Terminal Acetylation Quantitation.The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.Methionine as translation start signal: a review of the enzymes of the pathway in Escherichia coli.Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis.N-terminal modifications contribute to flowering time and immune response regulations.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Thierry Meinnel
@ast
Thierry Meinnel
@en
Thierry Meinnel
@es
Thierry Meinnel
@nl
Thierry Meinnel
@sl
type
label
Thierry Meinnel
@ast
Thierry Meinnel
@en
Thierry Meinnel
@es
Thierry Meinnel
@nl
Thierry Meinnel
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prefLabel
Thierry Meinnel
@ast
Thierry Meinnel
@en
Thierry Meinnel
@es
Thierry Meinnel
@nl
Thierry Meinnel
@sl
P106
P1153
7003509733
P21
P31
P496
0000-0001-5642-8637