Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition.
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Identification of essential active-site residues in ornithine decarboxylase of Nicotiana glutinosa decarboxylating both L-ornithine and L-lysineRegulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomesA molecular mechanism for eflornithine resistance in African trypanosomesMultiple active conformers of mouse ornithine decarboxylasePolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesOptimization of a non-radioactive high-throughput assay for decarboxylase enzymes.Mouse ornithine decarboxylase gene: cloning, structure, and expression.Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylaseThe ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis.Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.Cloning and expression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma brucei.Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to D,L-alpha-difluoromethylornithine.Spermidine synthase is required for virulence of Leishmania donovani.Requirement of a polypyrimidine tract for trans-splicing in trypanosomes: discriminating the PARP promoter from the immediately adjacent 3' splice acceptor site.Cloning of a trypanosomatid gene coding for an ornithine decarboxylase that is metabolically unstable even though it lacks the C-terminal degradation domain.Molecular cloning and characterization of ornithine decarboxylase cDNA of the nematode Panagrellus redivivusGenomic organization, chromosomal localization, and developmentally regulated expression of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma bruceiValidation of spermidine synthase as a drug target in African trypanosomes.Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.Panagrellus redivivus ornithine decarboxylase: structure of the gene, expression in Escherichia coli and characterization of the recombinant protein.Regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme.RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructsAn efficient method for stable transfection of bloodstream-form Trypanosoma brucei.Nucleotide sequence of the Chinese hamster ornithine decarboxylase gene.Rapid and regulated degradation of ornithine decarboxylase.Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation.Degradation of ornithine decarboxylase: exposure of the C-terminal target by a polyamine-inducible inhibitory protein.Molecular cloning and functional identification of a plant ornithine decarboxylase cDNA.Distinct domains of antizyme required for binding and proteolysis of ornithine decarboxylase.Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover.Characterization of a high-affinity membrane-associated ornithine decarboxylase from the free-living nematode Caenorhabditis elegansAntitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine.Regulation by polyamines of ornithine decarboxylase activity and cell division in the unicellular green alga Chlamydomonas reinhardtii.New insights in staging and chemotherapy of African trypanosomiasis and possible contribution of medicinal plants.
P2860
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P2860
Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
Cloning and sequencing of the ...... oromethylornithine inhibition.
@en
Cloning and sequencing of the ...... oromethylornithine inhibition.
@nl
type
label
Cloning and sequencing of the ...... oromethylornithine inhibition.
@en
Cloning and sequencing of the ...... oromethylornithine inhibition.
@nl
prefLabel
Cloning and sequencing of the ...... oromethylornithine inhibition.
@en
Cloning and sequencing of the ...... oromethylornithine inhibition.
@nl
P2093
P1476
Cloning and sequencing of the ...... uoromethylornithine inhibition
@en
P2093
P304
P407
P577
1987-06-01T00:00:00Z