Rescue of an abasic hairpin ribozyme by cationic nucleobases: evidence for a novel mechanism of RNA catalysis.
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A comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilizationStructural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozymeIdentification of an Imino Group Indispensable for Cleavage by a Small RibozymeWater in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transferThe glmS ribozyme: use of a small molecule coenzyme by a gene-regulatory RNASmall self-cleaving ribozymesDo the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data.Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.The catalytic diversity of RNAs.Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme.Chemical rescue, multiple ionizable groups, and general acid-base catalysis in the HDV genomic ribozyme.The pH dependence of hairpin ribozyme catalysis reflects ionization of an active site adenineThe hairpin ribozyme.Single-molecule enzymology of RNA: essential functional groups impact catalysis from a distanceRibozyme catalysis: not different, just worse.A chemo-genetic approach for the study of nucleobase participation in nucleolytic ribozymes.Quantum mechanical/molecular mechanical simulation study of the mechanism of hairpin ribozyme catalysisMolecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme.Theoretical studies of RNA catalysis: hybrid QM/MM methods and their comparison with MD and QM.Cobalt(III)hexaammine-dependent photocrosslinks in the hairpin ribozyme.Catalysis by the nucleolytic ribozymes.In vitro selection of second site revertants analysis of the hairpin ribozyme active site.QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanisms.Fluorescent N2,N3-epsilon-adenine nucleoside and nucleotide probes: synthesis, spectroscopic properties, and biochemical evaluation.Extensive molecular dynamics simulations showing that canonical G8 and protonated A38H+ forms are most consistent with crystal structures of hairpin ribozyme.General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation.Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme.In vitro selection of adenine-dependent hairpin ribozymes.Functional analysis of hairpin ribozyme active site architecture.
P2860
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P2860
Rescue of an abasic hairpin ribozyme by cationic nucleobases: evidence for a novel mechanism of RNA catalysis.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Rescue of an abasic hairpin ri ...... el mechanism of RNA catalysis.
@en
Rescue of an abasic hairpin ri ...... el mechanism of RNA catalysis.
@nl
type
label
Rescue of an abasic hairpin ri ...... el mechanism of RNA catalysis.
@en
Rescue of an abasic hairpin ri ...... el mechanism of RNA catalysis.
@nl
prefLabel
Rescue of an abasic hairpin ri ...... el mechanism of RNA catalysis.
@en
Rescue of an abasic hairpin ri ...... el mechanism of RNA catalysis.
@nl
P2093
P1476
Rescue of an abasic hairpin ri ...... el mechanism of RNA catalysis.
@en
P2093
Iaroslav I Kuzmine
Lori L Lebruska
Martha J Fedor
P304
P356
10.1016/S1074-5521(02)00130-8
P577
2002-04-01T00:00:00Z