Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.
about
Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular responseTransient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virusVirological and cellular roles of the transcriptional coactivator LEDGF/p75Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationA tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivoImpact of Chromatin on HIV ReplicationStructural basis for functional tetramerization of lentiviral integraseEmbryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Micep12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomesA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based DesignCrystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding siteSolution structure of the HIV-1 integrase-binding domain in LEDGF/p75LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactorsThe Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complexIntegration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner earNuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domainInteraction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromerRetroviral DNA IntegrationLEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivityDifferential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integrationHRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Integration site selection by retroviral vectors: molecular mechanism and clinical consequences.An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic proteinEpigenetic control of mobile DNA as an interface between experience and genome change.Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystemsLEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Mechanisms and inhibition of HIV integrationSUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter.Methods for integration site distribution analyses in animal cell genomesStructural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINsSeeing is believing: structure of the catalytic domain of HIV-1 integrase in complex with human LEDGF/p75.Molecular mechanisms of retroviral integration site selection.Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.
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P2860
Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Identification of the LEDGF/p7 ...... dependent chromatin tethering.
@en
Identification of the LEDGF/p7 ...... dependent chromatin tethering.
@nl
type
label
Identification of the LEDGF/p7 ...... dependent chromatin tethering.
@en
Identification of the LEDGF/p7 ...... dependent chromatin tethering.
@nl
prefLabel
Identification of the LEDGF/p7 ...... dependent chromatin tethering.
@en
Identification of the LEDGF/p7 ...... dependent chromatin tethering.
@nl
P2093
P356
P1476
Identification of the LEDGF/p7 ...... dependent chromatin tethering.
@en
P2093
Daniah Thompson
Eric Poeschla
Manuel Llano
Maria Vanegas
Mary Peretz
Sharon Delgado
P304
P356
10.1242/JCS.02299
P407
P577
2005-03-29T00:00:00Z