Akt activation by growth factors is a multiple-step process: the role of the PH domain.
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MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavagesmTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptideP90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferationThe E3 ligase TRAF6 regulates Akt ubiquitination and activationRegulated association of protein kinase B/Akt with breast tumor kinaseClipR-59 interacts with Akt and regulates Akt cellular compartmentalizationPar-4 inhibits Akt and suppresses Ras-induced lung tumorigenesisReciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditionsEssential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingAkt phosphorylates and regulates the orphan nuclear receptor Nur77Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer developmentTcl1 enhances Akt kinase activity and mediates its nuclear translocationTyrosine kinase signalling in breast cancer: tyrosine kinase-mediated signal transduction in transgenic mouse models of human breast cancer.Developmental disease and cancer: biological and clinical overlapsBinding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changeCrystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase InhibitionThe biology behind PI3K inhibition in chronic lymphocytic leukaemiaCLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosisRegulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation siteProtein kinase B is regulated in platelets by the collagen receptor glycoprotein VICross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediatorsOverexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Aktα-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutationNF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromiumInsulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targetsMechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylationRas GTPase-activating protein binds to Akt and is required for its activationDefective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CPhysical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinaseERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsA Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling.Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts.Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation.Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.Caspase-3 activation as a bifurcation point between plasticity and cell death.Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.
P2860
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P2860
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
@en
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
@nl
type
label
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
@en
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
@nl
prefLabel
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
@en
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
@nl
P2093
P356
P1433
P1476
Akt activation by growth factors is a multiple-step process: the role of the PH domain.
@en
P2093
Bellacosa A
Malstrom S
McCormick F
Tsichlis P
P2888
P304
P356
10.1038/SJ.ONC.1201947
P407
P577
1998-07-01T00:00:00Z
P5875
P6179
1018076908