Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms. - Wikidata - awgldk - TriplyDB

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

http://www.wikidata.org/entity/Q42830477

about

TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8 The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics Pharmacology of manipulating lean body mass TWEAK and the progression of renal disease: clinical translation Advances in anticancer immunotoxin therapy Inflammatory cytokines and survival factors from serum modulate tweak-induced apoptosis in PC-3 prostate cancer cells.Predictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenografts TWEAK-independent Fn14 self-association and NF-κB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domain Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.Fn14•TRAIL effectively inhibits hepatocellular carcinoma growth.Development of an Fn14 agonistic antibody as an anti-tumor agent.Fn14 receptor promotes invasive potential and metastatic capacity of non-small lung adenocarcinoma cells through the up-regulation of integrin α6 Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer.Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells.Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb.The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment Clinical targeting of the TNF and TNFR superfamilies Antitumor activity of a humanized, bivalent immunotoxin targeting fn14-positive solid tumors Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR.TWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion.Radioimmunotherapy of solid tumors: searching for the right target.The TWEAK-Fn14 system as a potential drug target.TWEAK/Fn14 signaling in tumors.Disease-Induced Skeletal Muscle Atrophy and Fatigue.TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells.A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo.Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity.The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models.Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion.TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic.Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis.Phase 1 study of enavatuzumab, a first-in-class humanized monoclonal antibody targeting the TWEAK receptor, in patients with advanced solid tumors.Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas.Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins

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Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

http://www.wikidata.org/entity/Q42830477

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

@en

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

@nl

type

label

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

@en

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

@nl

prefLabel

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

@en

Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

@nl

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1078-0432.CCR-09-1929

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Clinical Cancer Research

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Antibodies to TWEAK receptor inhibit human tumor growth through dual mechanisms.

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David B Powers

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Debra T Chao

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Donghee Choi

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Eric D Hsi

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Ferdinand Evangelista

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Jennifer Grove

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Johnny Yin

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Marie Cardenas

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Marjorie James

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Melanie H L Wong

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497-508

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scholarly article

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10.1158/1078-0432.CCR-09-1929

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2

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20068083

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