Structural changes in factor VIIa induced by Ca2+ and tissue factor studied using circular dichroism spectroscopy
about
Structure of human factor VIIa and its implications for the triggering of blood coagulationMechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa ActivitySpin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites.Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic activity.Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa ActivityEssential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation.Properties of spin and fluorescent labels at a receptor-ligand interface.Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain.Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor.Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factorAugmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement.A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation.The length of the linker between the epidermal growth factor-like domains in factor VIIa is critical for a productive interaction with tissue factor.Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry.Assignment of molecular properties of a superactive coagulation factor VIIa variant to individual amino acid changes.Characterization of canine coagulation factor VII and its complex formation with tissue factor: canine-human cross-species compatibility.Biochemical characterization of LR769, a new recombinant factor VIIa bypassing agent produced in the milk of transgenic rabbits.Bioengineering of rFVIIa Biopharmaceutical and Structure Characterization for Biosimilarity Assessment.Synthesis and characterization of (18)F-labeled active site inhibited factor VII (ASIS).Recombinant coagulation factor VIIa labelled with the fac-99 mTc(CO)3-core: synthesis and in vitro evaluation of a putative new radiopharmaceutical for imaging in acute bleeding lesionA loop of coagulation factor VIIa influencing macromolecular substrate specificity
P2860
Q27619263-3AAD13F3-CD14-4EAE-A679-31C9F5F7B8C8Q27651260-7A0DF6D3-83BC-4D06-A32A-D688AB30F2FCQ28359682-BFEC6EAE-5A14-4127-BC21-77E57F31F7BEQ33949632-14E10C96-CA77-4548-92AD-9D5E99B59856Q33949866-106506FB-B3E7-48C2-B8A8-4D5781B619BEQ39677195-486A1965-223D-409B-8075-BD2E0354A6FCQ39941840-2B9B43FB-38F8-46A7-97FC-4894F6D099E5Q40151903-A5051AE7-A43B-4B9C-B54B-4E684B264C22Q40941447-B35B61E7-2B98-432F-8651-77771E9534EBQ41110995-7F9379A6-02E3-4AD5-9D44-941CA0B896ACQ41772230-06CFA73B-507F-4302-B8C9-C27911F35E23Q41876554-41EC7FDF-4DB6-4D46-BA67-C040E73BD09EQ42229620-C0755065-EB43-45A8-ABB8-816272AA9811Q43053276-3EC35236-358D-4FD0-B05C-519DF6F00A2FQ43072186-113257D8-A543-4252-B1FF-AC08FD3366BDQ44224718-412F54A5-D377-4B70-A2E4-066719AD0ECDQ45859525-F4D632EB-1554-4A64-9190-DD2D78F38268Q45868639-9D6FB778-07BB-4FAB-91BE-F1895EE747BFQ48207455-24CADF76-4993-4CDE-8A23-C71784CB5A51Q53562827-57496C94-439E-4D33-8A4E-3155D45A106FQ57681765-93988F3D-188F-4B9A-BDB2-08438712AF66Q58211010-41049021-F0BE-4713-8985-6460612D550E
P2860
Structural changes in factor VIIa induced by Ca2+ and tissue factor studied using circular dichroism spectroscopy
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Structural changes in factor V ...... ircular dichroism spectroscopy
@en
Structural changes in factor V ...... ircular dichroism spectroscopy
@nl
type
label
Structural changes in factor V ...... ircular dichroism spectroscopy
@en
Structural changes in factor V ...... ircular dichroism spectroscopy
@nl
prefLabel
Structural changes in factor V ...... ircular dichroism spectroscopy
@en
Structural changes in factor V ...... ircular dichroism spectroscopy
@nl
P2093
P2860
P356
P1433
P1476
Structural changes in factor V ...... ircular dichroism spectroscopy
@en
P2093
P2860
P304
P356
10.1002/PRO.5560050809
P577
1996-08-01T00:00:00Z