Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment.
about
Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetesIdentification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragmentQuantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes typeDemonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2.Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylaseA comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants.Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes.T-lymphocytes and the pathogenesis of type 1 (insulin-dependent) diabetes mellitus.Relationships among 64k autoantibodies, pancreatic beta-cell function, HLA-DR antigens and HLA-DQ genes in patients with insulin-dependent diabetes mellitus in Korea.The stages of type 1A diabetes: 2005.Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylaseAn islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies.Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus.Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1.Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).Autoantibodies in insulin-dependent diabetes mellitus.Prediction and prevention of type I diabetes.Immunological studies on type 1 diabetes in identical twinsCharacterization of distinct islet protein autoantigens associated with type 1 diabetes.Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus.Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity.Islet cell autoantigens in type 1 diabetes.Antibody screening in a population of children.Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndromeGlucose intolerance and diabetes following antigen-specific insulitis in diabetes-susceptible "humanized" transgenic mice.Epitope analysis of insulin autoantibodies using recombinant Fab.Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules.Combined analysis of islet cell antibodies which cross-react with mouse pancreas, antibodies to the M(r) 64,000 islet protein, and antibodies to glutamate decarboxylase in subjects at risk for IDDM.A 64 kDa membrane antigen is a recurrent epitope for natural autoantibodies in patients with Graves' thyroid and ophthalmic diseases.Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM.Detection and immunochemical characterization of glutamic acid decarboxylase autoantibodies in patients with autoimmune diabetes mellitus.Re-exposure to beta cell autoantigens in pancreatic allograft recipients with preexisting beta cell autoantibodies.
P2860
Q24322739-AF9FD74C-902E-4630-B4C3-D7482A6EADE6Q24567712-8A4C9E44-352B-4865-92FE-49BE937B278CQ24617932-8B3D63F1-7B82-4EF8-9A89-4C1AFAC990DBQ33899197-CA2B34A6-9F62-49EB-8651-D81EE060A79FQ33906397-DEE8D840-D205-4419-AFFD-A2E25B9B37B0Q34111857-9C23FAE3-D1B4-4844-A1F9-CD34E508E246Q34200419-EC353EBC-3835-41C9-9D49-7611FFBD5293Q34737274-542A4728-5E42-4474-8668-7AFA0E52E57CQ35654189-3C4B9616-7C7D-46AC-8C42-7B11598578B6Q35938847-122F7265-13D0-4711-9BCC-EFD44AEF9F10Q36079915-0055604D-F725-4E53-8D86-592AA84F6DB0Q36202374-A8BCC9F9-84A6-4397-BC64-B91BBB37D6CFQ36853549-4F609848-3917-4AC6-B44D-9B977479D76BQ37248995-483276CB-DEDD-4DA3-A917-B4916A7FD7F0Q37356382-892B028F-FE7E-4DCB-AF22-CCD5D63A1EA3Q37421850-FC5F84B0-D444-4F6C-85FA-4E36E07A6119Q37437161-F970DE5F-B943-42F5-8F1B-D6780F48CFDCQ38291962-175DA103-EDCE-4783-917D-07A87BF878F4Q40575841-62C901E8-01D4-483F-AC38-A019794ADD72Q40575846-A8A17AF8-A624-41BE-955B-6F9CDC51A6D8Q40667973-6B3B4C4C-708F-4DFE-A1BF-CC80A6A0907EQ40770672-68A2D0AB-5D38-484F-9F6C-46C474BD5D58Q40870952-3DE5167A-FBAB-4D29-9764-274068806B78Q40981495-8FDC5184-6F22-4A4E-97CB-5069B8BA8193Q41205349-6744B6CD-7D1E-4C7D-9EED-BBAF3D49F558Q41695578-DD84D563-4E7F-4385-BEE6-4EAD1FB20EFAQ41994256-630C7FF9-EE66-4593-AE74-0A09DF6EBD73Q42725609-3460EAC2-22C0-481F-A819-A2F804CE691CQ46485478-9CCCFD74-1F52-4A00-9FF6-3C21257BCBB5Q47935660-A0709F0A-C8AD-422E-90EE-344C02F16BAFQ48131328-C6DE07E2-EEA2-41A9-A96C-1F9DF9AB3B22Q48619925-C0576DD0-6A4A-4AD5-AFE2-100F030390D8Q50864565-03D43EF0-EF47-4DE3-8261-40D1F36BD205Q51790735-057CE168-825F-49DB-BE41-D20D63D78EFAQ52923274-BAD077C4-9271-4CB9-B35C-C07CDA3DEE57
P2860
Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Distinct antibody specificitie ...... revealed by trypsin treatment.
@en
Distinct antibody specificitie ...... revealed by trypsin treatment.
@nl
type
label
Distinct antibody specificitie ...... revealed by trypsin treatment.
@en
Distinct antibody specificitie ...... revealed by trypsin treatment.
@nl
prefLabel
Distinct antibody specificitie ...... revealed by trypsin treatment.
@en
Distinct antibody specificitie ...... revealed by trypsin treatment.
@nl
P2093
P2860
P356
P1476
Distinct antibody specificitie ...... revealed by trypsin treatment.
@en
P2093
Champagne P
Christie MR
Delovitch TL
P2860
P304
P356
10.1084/JEM.172.3.789
P407
P577
1990-09-01T00:00:00Z