Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. - Wikidata - awgldk - TriplyDB

Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.

Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.

http://www.wikidata.org/entity/Q42953996

about

Imaging alterations of cardiomyocyte cAMP microdomains in disease Studying GPCR/cAMP pharmacology from the perspective of cellular structure Therapeutic potential of PDE modulation in treating heart disease Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice Functional antagonism of β-adrenoceptor subtypes in the catecholamine-induced automatism in rat myocardium.Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II Cardiac cyclic nucleotide phosphodiesterases: function, regulation, and therapeutic prospects.Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.Constitutive expression of Gsα(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history.Conserved expression and functions of PDE4 in rodent and human heart.Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats.UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway.Compartmentalization of beta-adrenergic signals in cardiomyocytes.Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.Compartmentation of cAMP signalling in cardiomyocytes in health and disease.Biophysical techniques for detection of cAMP and cGMP in living cells.Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases.Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation.Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes.Rapid effects of aldosterone in primary cultures of cardiomyocytes - do they suggest the existence of a membrane-bound receptor?The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway.Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes.Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease.PDE4-Mediated cAMP Signalling.Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System.Meeting highlights from the 2010 European society of cardiology heart failure association winter meeting: translational heart failure research.miR-133: A Suppressor of Cardiac Remodeling?

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P2860

Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals.

http://www.wikidata.org/entity/Q42953996

description

2009 nî lūn-bûn

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2009年の論文

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2009年論文

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

Decreased expression and activ ...... beta-adrenergic cAMP signals.

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Decreased expression and activ ...... beta-adrenergic cAMP signals.

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Circulation Research

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Decreased expression and activ ...... beta-adrenergic cAMP signals.

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Aniella Abi-Gerges

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Audrey Varin

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Christophe Heymes

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Claire Lugnier

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Florence Lefebvre

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Grégoire Vandecasteele

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Marco Conti

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Philippe Mateo

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Rodolphe Fischmeister

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P2860

Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

Cardiac excitation-contraction coupling

Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy

Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family.

A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.

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8

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105

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Rodolphe Fischmeister

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19745166

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