GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis. - Wikidata - awgldk - TriplyDB

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

http://www.wikidata.org/entity/Q43046232

about

Glucagon secretion and signaling in the development of diabetes CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?Cardiovascular effects of glucagon-like peptide 1 (GLP-1) receptor agonists Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.Diabetes resolution and hyperinsulinaemia after metabolic Roux-en-Y gastric bypass.A comparative analysis of human and mouse islet G-protein coupled receptor expression.CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.Benefits of healthy adipose tissue in the treatment of diabetes.Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion.Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats Minireview: Glucagon in stress and energy homeostasis.A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration.DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP Additive effects of miglitol and anagliptin on insulin-treated type 2 diabetes mellitus: a case study.Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications.Chronic exposure to GLP-1 increases GLP-1 synthesis and release in a pancreatic alpha cell line (α-TC1): evidence of a direct effect of GLP-1 on pancreatic alpha cells Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.A novel GPR40 agonist, CNX-011-67, suppresses glucagon secretion in pancreatic islets under chronic glucolipotoxic conditions in vitro.TASK-1 Potassium Channels Limit Pancreatic α-Cell Calcium Influx and Glucagon Secretion.Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets.Mathematical Modeling of Interacting Glucose-Sensing Mechanisms and Electrical Activity Underlying Glucagon-Like Peptide 1 Secretion Transient overexpression of cyclin D2/CDK4/GLP1 genes induces proliferation and differentiation of adult pancreatic progenitors and mediates islet regeneration Stabilization of postprandial blood glucose fluctuations by addition of glucagon like polypeptide-analog administration to intensive insulin therapy.Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and (19)F-NMR.Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity.A computational systems analysis of factors regulating α cell glucagon secretion.(111)In-exendin uptake in the pancreas correlates with the β-cell mass and not with the α-cell mass Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.Growth factor signalling in the regulation of α-cell fate.Regulation of glucagon secretion by incretins.Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?Regulation of calcium in pancreatic α- and β-cells in health and disease.Adipose tissue, hormones, and treatment of type 1 diabetes.The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders.K(ATP) channels and islet hormone secretion: new insights and controversies.

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GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

http://www.wikidata.org/entity/Q43046232

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

2010年學術文章

@zh-hant

name

GLP-1 inhibits and adrenaline ...... channel-dependent exocytosis.

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GLP-1 inhibits and adrenaline ...... channel-dependent exocytosis.

@nl

type

label

GLP-1 inhibits and adrenaline ...... channel-dependent exocytosis.

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GLP-1 inhibits and adrenaline ...... channel-dependent exocytosis.

@nl

prefLabel

GLP-1 inhibits and adrenaline ...... channel-dependent exocytosis.

@en

GLP-1 inhibits and adrenaline ...... channel-dependent exocytosis.

@nl

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J.CMET.2010.04.007

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Cell Metabolism

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Anders Rosengren

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Caroline E Ward

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Erik Renström

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Fernando Abdulkader

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Martin Bengtsson

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Matthias Braun

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Orit Braha

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Quan Zhang

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Reshma Ramracheya

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Stefan Amisten

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P2860

Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis.

Alpha cell function in health and disease: influence of glucagon-like peptide-1.

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes.

Glucose sensing in L cells: a primary cell study.

Blood sampling methodology is crucial for precise measurement of plasma catecholamines concentrations in mice.

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