Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice. - Wikidata - awgldk - TriplyDB

Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.

Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.

http://www.wikidata.org/entity/Q43100244

about

Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound Immunohistochemical detection of transgene expression in the brain using small epitope tags.Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells.Clinical genetics of Alzheimer's disease Hsc70 rapidly engages tau after microtubule destabilization Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.Versatile somatic gene transfer for modeling neurodegenerative diseases.Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice.Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.Protective effect of bone marrow mesenchymal stem cells on PC12 cells apoptosis mediated by TAG1 The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease.Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury.Medical bioremediation of age-related diseases.AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.Gene therapy in Alzheimer's disease - potential for disease modification The neuroprotective effect of immune serum of adeno-associated virus vaccine containing Aβ1-15 gene on amyloid toxicity.Dynamic alteration of neprilysin and endothelin-converting enzyme in age-dependent APPswe/PS1dE9 mouse model of Alzheimer's disease.Gene therapy for neurological disorders.Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice Androgen alleviates neurotoxicity of β-amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ.Photodegradation of β-sheet amyloid fibrils associated with Alzheimer's disease by using polyoxometalates as photocatalysts.Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice Neuro-Immuno-Gene- and Genome-Editing-Therapy for Alzheimer's Disease: Are We There Yet?

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Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.

http://www.wikidata.org/entity/Q43100244

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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Adeno-associated viral (AAV) s ...... in APP + PS1 transgenic mice.

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Adeno-associated viral (AAV) s ...... in APP + PS1 transgenic mice.

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Molecular Therapy

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Adeno-associated viral (AAV) s ...... in APP + PS1 transgenic mice.

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Craig Meyers

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Daniel Lee

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Dave Morgan

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Kevin Nash

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Marcia N Gordon

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Mary Mercer

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Nicholas Muzyczka

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Paul E Gottschall

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P2860

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11

Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ.

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.

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1580-1586

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10.1038/MT.2008.148

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9

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