Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
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A THEMIS:SHP1 complex promotes T-cell survivalConvergence of Innate and Adaptive Immunity during Human AgingAbsence of the adaptor protein Shb potentiates the T helper type 2 response in a mouse model of atopic dermatitisThe lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cellsQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hubRole of LAT in the granule-mediated cytotoxicity of CD8 T cells.Molecular mechanisms underlying the evolution of the slp76 signalosome.T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools.T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo.Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expressionMislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody productionCoordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.The importance of LAT in the activation, homeostasis, and regulatory function of T cellsCD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction.LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?miRNA signature of mouse helper T cell hyper-proliferationQuantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation.Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathwayDominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T CellsA Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclustersA phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylationTNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapterMurine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.Phorbol ester-mediated re-expression of endogenous LAT adapter in J.CaM2 cells: a model for dissecting drivers and blockers of LAT transcription.The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells.Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.The LAT story: a tale of cooperativity, coordination, and choreography.Signaling microdomains in T cells.Altered T-cell receptor signaling in the pathogenesis of allergic disease.New insights into the T cell synapse from single molecule techniques.The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.T cell antigen receptor activation and actin cytoskeleton remodeling.
P2860
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P2860
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Loss of the LAT adaptor conver ...... dently of the T cell receptor.
@en
Loss of the LAT adaptor conver ...... dently of the T cell receptor.
@nl
type
label
Loss of the LAT adaptor conver ...... dently of the T cell receptor.
@en
Loss of the LAT adaptor conver ...... dently of the T cell receptor.
@nl
prefLabel
Loss of the LAT adaptor conver ...... dently of the T cell receptor.
@en
Loss of the LAT adaptor conver ...... dently of the T cell receptor.
@nl
P2093
P50
P1433
P1476
Loss of the LAT adaptor conver ...... dently of the T cell receptor.
@en
P2093
Amandine Sansoni
Claude Grégoire
Elodie Bertosio
Michael Mingueneau
Pierre Perrin
Richard M Locksley
Sylvie Richelme
P304
P356
10.1016/J.IMMUNI.2009.05.013
P407
P50
P577
2009-08-13T00:00:00Z