The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter.
about
R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuseStudies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine releaseBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesRole of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuseRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsσ Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-AdministrationAllosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter.Evidence for noncompetitive modulation of substrate-induced serotonin release.Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications.Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.Membrane cholesterol modulates the outward facing conformation of the dopamine transporter and alters cocaine binding.Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transportersMutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions.Mutations at tyrosine 88, lysine 92 and tyrosine 470 of human dopamine transporter result in an attenuation of HIV-1 Tat-induced inhibition of dopamine transport.2-Substituted 3β-Aryltropane Cocaine Analogs Produce Atypical Effects without Inducing Inward-Facing Dopamine Transporter Conformations.SLC6 transporters: structure, function, regulation, disease association and therapeuticsRegulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole.Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity.Preference for distinct functional conformations of the dopamine transporter alters the relationship between subjective effects of cocaine and stimulation of mesolimbic dopamineAntagonist-induced conformational changes in dopamine transporter extracellular loop two involve residues in a potential salt bridgeDecreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors.Dopamine transporter-dependent and -independent striatal binding of the benztropine analog JHW 007, a cocaine antagonist with low abuse liability.Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.Irreversible binding of a novel phenylisothiocyanate tropane analog to monoamine transporters in rat brainRelations between stimulation of mesolimbic dopamine and place conditioning in rats produced by cocaine or drugs that are tolerant to dopamine transporter conformational change.2-isoxazol-3-phenyltropane derivatives of cocaine: molecular and atypical system effects at the dopamine transporter.Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter.A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.(±)-2-(N-tert-Butylamino)-3'-[(125)I]-iodo-4'-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban).Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.The human dopamine transporter forms a tetramer in the plasma membrane: cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs.A cocaine insensitive chimeric insect serotonin transporter reveals domains critical for cocaine interaction.Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3 alpha-(4-fluorophenyl)tropane.The role of human dopamine transporter in NeuroAIDS.State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum.
P2860
Q24621917-FC893D62-2148-4CD5-BAC0-937BFD08E63CQ24655326-CD4C7DD2-50B0-4B7E-9A58-048BF38B5921Q26829749-7EAFA548-147D-4169-A011-BDC6AF084EDEQ26853319-DBEB8C86-D5AB-44E8-BC33-30933666E85AQ28306056-C84E51EA-49B1-4FEE-B86D-351753917A8DQ28476265-55E6B21B-23E6-498F-ADE9-AE1D6D1C3B90Q28477546-1A24162F-3468-4E71-9146-DA65741DEEB9Q33754479-D69F20B0-29D7-4D55-9C31-3A536E3B43F1Q33808035-22EDF77C-D203-456A-B7A5-77F5B27DCD3BQ34135689-E15DB664-0F2C-462E-9386-1F13BA876D4AQ34136977-389256E3-16AB-47A0-9C7C-D7F916A306D7Q34153285-71CBB29F-4410-4DD0-945C-9617426A78DBQ34186694-8D507D8A-4160-4D76-87CD-1B6D47B95F2FQ34249270-1C73D248-87D2-4A65-8B08-97F51D2377A2Q34343025-AAB48900-46F6-4F14-9A4C-1AC8A86E0EFDQ34458860-C66D41C5-6878-4F0F-BBF9-92C72E2510D2Q34509115-C0693DA6-1315-4597-8A6B-A073E25D0320Q34649517-9FC96F07-0363-4AC4-813A-B04A9845DE93Q34673305-FC54BE4F-62A9-4FD4-B0FC-7966BF077870Q34811630-EBFCB1DA-3998-4332-9438-9B5E8C5744FFQ34825605-6615EE34-5D9C-4044-AF18-DC09E553C121Q34984055-C96C4356-FAD2-44EA-94DA-4D4968D0867FQ35160057-BDC2034D-5A7F-4B65-9BEC-F16E9F8BF920Q35383366-DAF6626B-E3A1-4DDA-8E87-0290F755A112Q35429841-7645D044-C143-4642-8DBA-04950368A949Q35454366-4F78CA1C-39FB-41B7-8AEC-FC59F667895DQ36335545-9B0B048B-8F27-45A4-A850-039EB9AF8504Q36429668-ED13853E-65E6-4F6F-9D92-E7FBA5428973Q37135116-23B73643-F0C8-46A0-9EE6-5D4249207C9AQ37707743-D0A1C1CD-002E-4BBB-8129-05B5F4930DC9Q39753107-C86BDE79-F6B3-48BD-83D0-C40444043123Q39851539-4412758F-5620-4E0E-BD12-AA58ADF45D8BQ40079534-C1B8B351-A565-4614-BC9E-4396EC543189Q40556741-5E44A22B-4B91-45C6-A6EA-3B0CD92CE8B8Q40609766-0C54DE5B-65B9-4FFF-86AD-AC1941533DBEQ40629961-AA3F3ECD-4CF2-42E4-B75E-9EBE160F04DEQ40710566-68792475-C981-4CFA-ABB8-529120646AADQ40724489-DC61D12F-2BC7-4427-9127-A833FDB222CBQ41922188-BF113C81-BC5C-47E8-A325-0F919457A63FQ42689431-28EB781B-538A-4987-8B3B-7BD31AC3F659
P2860
The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
The uptake inhibitors cocaine ...... he human dopamine transporter.
@en
The uptake inhibitors cocaine ...... he human dopamine transporter.
@nl
type
label
The uptake inhibitors cocaine ...... he human dopamine transporter.
@en
The uptake inhibitors cocaine ...... he human dopamine transporter.
@nl
prefLabel
The uptake inhibitors cocaine ...... he human dopamine transporter.
@en
The uptake inhibitors cocaine ...... he human dopamine transporter.
@nl
P2093
P2860
P356
P1476
The uptake inhibitors cocaine ...... he human dopamine transporter.
@en
P2093
P2860
P304
29012-29018
P356
10.1074/JBC.M011785200
P407
P577
2001-06-06T00:00:00Z