about
R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuseTurning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease PathogenesisModeling and dynamics of the inward-facing state of a Na+/Cl- dependent neurotransmitter transporter homologueThe glial and the neuronal glycine transporters differ in their reactivity to sulfhydryl reagentsMutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactionsRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersA conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterLigand effects on cross-linking support a conformational mechanism for serotonin transport.Transmembrane domain 6 of the human serotonin transporter contributes to an aqueously accessible binding pocket for serotonin and the psychostimulant 3,4-methylene dioxymethamphetamine.Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway.Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.Cytoplasmic permeation pathway of neurotransmitter transporters.Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway.Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.Substituted cysteine accessibility of the third transmembrane domain of the creatine transporter: defining a transport pathway.Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters.Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters.Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.Mechanism for alternating access in neurotransmitter transporters.Accessibility of cysteine residues substituted into the cytoplasmic regions of the alpha-factor receptor identifies the intracellular residues that are available for G protein interaction.Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?Understanding the molecular pharmacology of the serotonergic system: using fluoxetine as a model.An intracellular interaction network regulates conformational transitions in the dopamine transporter.Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site.Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.Cysteine 144 in the third transmembrane domain of the creatine transporter is located close to a substrate-binding site.Transmembrane domain 8 of the {gamma}-aminobutyric acid transporter GAT-1 lines a cytoplasmic accessibility pathway into its binding pocket.The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents.The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter.A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109.Substrate-induced conformational changes of extracellular loop 1 in the glycine transporter GLYT2.A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter.Proximity of two oppositely oriented reentrant loops in the glutamate transporter GLT-1 identified by paired cysteine mutagenesis.Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter.Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I.Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.The second intracellular loop of the glycine transporter 2 contains crucial residues for glycine transport and phorbol ester-induced regulation.
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Permeation and gating residues in serotonin transporter
@ast
Permeation and gating residues in serotonin transporter
@en
type
label
Permeation and gating residues in serotonin transporter
@ast
Permeation and gating residues in serotonin transporter
@en
prefLabel
Permeation and gating residues in serotonin transporter
@ast
Permeation and gating residues in serotonin transporter
@en
P2860
P356
P1476
Permeation and gating residues in serotonin transporter
@en
P2093
P2860
P304
P356
10.1073/PNAS.97.3.1044
P407
P577
2000-02-01T00:00:00Z