Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans.
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Evolution of ventricular myocyte electrophysiology.A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.Restitution slope is principally determined by steady-state action potential duration.Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potentialAsymmetry in membrane responses to electric shocks: insights from bidomain simulations.HERG channel (dys)function revealed by dynamic action potential clamp techniqueSubunit interaction determines IKs participation in cardiac repolarization and repolarization reserveModelling and imaging cardiac repolarization abnormalities.Computational biology in the study of cardiac ion channels and cell electrophysiology.The electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk.A Parsimonious Model of the Rabbit Action Potential Elucidates the Minimal Physiological Requirements for Alternans and Spiral Wave Breakup.Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbitsAdrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs.Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysisStructural and regulatory evolution of cellular electrophysiological systems.Arrhythmogenic transient dynamics in cardiac myocytes.Supplemental studies for cardiovascular risk assessment in safety pharmacology: a critical overview.Role of abnormal repolarization in the mechanism of cardiac arrhythmia.Modeling of the adrenergic response of the human IKs current (hKCNQ1/hKCNE1) stably expressed in HEK-293 cells.Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles.Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles.Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes.Mechanosensitivity of GIRK channels is mediated by protein kinase C-dependent channel-phosphatidylinositol 4,5-bisphosphate interaction.Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes.Atrial selectivity in Na+channel blockade by acute amiodarone.Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs.I(Ks) blockade in border zone arrhythmias from guinea-pig ventricular myocardium submitted to simulated ischemia and reperfusion.Combined inhibition of key potassium currents has different effects on cardiac repolarization reserve and arrhythmia susceptibility in dogs and rabbits.Mechanism of doxorubicin cardiotoxicity evaluated by integrating multiple molecular effects into a biophysical model.The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug-induced Torsade de Pointes.β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle.Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.Inhibitory Effect of Vascular Endothelial Growth Factor on the Slowly Activating Delayed Rectifier Potassium Current in Guinea Pig Ventricular Myocytes.Role of slow delayed rectifying potassium current in dynamics of repolarization and electrical memory in swine ventricles.IKr and IKs remodeling differentially affects QT interval prolongation and dynamic adaptation to heart rate acceleration in bradycardic rabbits.Molecular basis of species-specific expression of repolarizing K+ currents in the heart.Torsades de Pointes in the Guinea-pig heart : editorial to: "dofetilide promotes repolarization abnormalities in perfused Guinea-pig heart" by O.E. OsadchiiMyocardial structural, contractile and electrophysiological changes in the guinea-pig heart failure model induced by chronic sympathetic activationMechanism of Action Potential Prolongation During Metabolic Inhibition in the Whole Rabbit Heart
P2860
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P2860
Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Density and kinetics of I
@nl
Density and kinetics of I(Kr) ...... or arrhythmogenesis in humans.
@en
type
label
Density and kinetics of I
@nl
Density and kinetics of I(Kr) ...... or arrhythmogenesis in humans.
@en
prefLabel
Density and kinetics of I
@nl
Density and kinetics of I(Kr) ...... or arrhythmogenesis in humans.
@en
P2093
P356
P1433
P1476
Density and kinetics of I(Kr) ...... or arrhythmogenesis in humans.
@en
P2093
P304
P356
10.1161/HC3401.093151
P407
P577
2001-08-01T00:00:00Z