Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells.
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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylationSuppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptorAltered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrestCRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysisp27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapyDeregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerReduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cellsTamoxifen may prevent both ER+ and ER- breast cancers and select for ER- carcinogenesis: an alternative hypothesis.Nodal signaling promotes a tumorigenic phenotype in human breast cancerTherapeutic CDK4/6 inhibition in breast cancer: key mechanisms of response and failure.MEN1, MEN4, and Carney Complex: Pathology and Molecular GeneticsPathways to tamoxifen resistance.Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells.Regulation of hormonal therapy resistance by cell cycle machinery.EGFR/HER2 inhibitor AEE788 increases ER-mediated transcription in HER2/ER-positive breast cancer cells but functions synergistically with endocrine therapy.ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer.Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth arrest versus proliferation response of MCF-7 breast cancer cells to phorbol ester.p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesisTumor suppressor p53 status does not determine the differentiation-associated G₁ cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D₃ and antioxidants.Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinasesTargeting the mitogen-activated protein kinase cascade to treat cancer.New insights on the role of hormonal therapy in ovarian cancerIsorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen‑activated protein kinase kinase signaling pathwaysInsulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein BimPhosphoproteomic Analysis Identifies Focal Adhesion Kinase 2 (FAK2) as a Potential Therapeutic Target for Tamoxifen Resistance in Breast Cancer.MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer.Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells.Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progressionSimvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway.GNA13 as a prognostic factor and mediator of gastric cancer progression.YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene ExpressionAssociations of proteins relevant to MAPK signaling pathway (p38MAPK-1,HIF-1 and HO-1) with coronary lesion characteristics and prognosis of peri-menopausal women.Clinical significance of cell cycle inhibitors in hepatocellular carcinoma.Role of miR-155 in drug resistance of breast cancer.Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes.Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane.Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells.Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth.
P2860
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P2860
Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Constitutive MEK/MAPK activation leads to p27
@nl
Constitutive MEK/MAPK activati ...... in human breast cancer cells.
@en
type
label
Constitutive MEK/MAPK activation leads to p27
@nl
Constitutive MEK/MAPK activati ...... in human breast cancer cells.
@en
prefLabel
Constitutive MEK/MAPK activation leads to p27
@nl
Constitutive MEK/MAPK activati ...... in human breast cancer cells.
@en
P2093
P2860
P356
P1476
Constitutive MEK/MAPK activati ...... in human breast cancer cells.
@en
P2093
Donovan JC
Slingerland JM
P2860
P304
40888-40895
P356
10.1074/JBC.M106448200
P407
P577
2001-08-29T00:00:00Z