Mechanisms for reversible regulation between G13 and Rho exchange factors. - Wikidata - awgldk - TriplyDB

Mechanisms for reversible regulation between G13 and Rho exchange factors.

Mechanisms for reversible regulation between G13 and Rho exchange factors.

http://www.wikidata.org/entity/Q43792221

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Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular Diseases Mechanisms regulating endothelial permeability Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF B plexins activate Rho through PDZ-RhoGEF Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK.Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13 Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitors.Lsc activity is controlled by oligomerization and regulates integrin adhesion.Is caveolin-1 a viable therapeutic target to reduce cancer metastasis?Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins.The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. 'Protein modifications: beyond the usual suspects' review series.A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.Regulation and physiological functions of G12/13-mediated signaling pathways.Regulation of RhoGEF proteins by G12/13-coupled receptors.Regulation of smooth muscle contraction by small GTPases.Carbohydrate chemistry in drug discovery.G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery.Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis.Selective Role of Vinculin in Contractile Mechanisms of Endothelial Permeability.

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P2860

Mechanisms for reversible regulation between G13 and Rho exchange factors.

http://www.wikidata.org/entity/Q43792221

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年學術文章

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2001年學術文章

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name

Mechanisms for reversible regulation between G13 and Rho exchange factors.

@en

Mechanisms for reversible regulation between G13 and Rho exchange factors.

@nl

type

label

Mechanisms for reversible regulation between G13 and Rho exchange factors.

@en

Mechanisms for reversible regulation between G13 and Rho exchange factors.

@nl

prefLabel

Mechanisms for reversible regulation between G13 and Rho exchange factors.

@en

Mechanisms for reversible regulation between G13 and Rho exchange factors.

@nl

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Journal of Biological Chemistry

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Mechanisms for reversible regulation between G13 and Rho exchange factors.

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P2093

Clark D Wells

http://www.w3.org/2001/XMLSchema#string

Jeffrey D Rothstein

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Mandy Jackson

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Mu-Ya Liu

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Pamela M Sternweis

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Paul C Sternweis

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Stephen Gutowski

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Tohru Kozasa

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P2860

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

Vascular system defects and impaired cell chemokinesis as a result of Galpha13 deficiency

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits

Structural basis of the Axin-adenomatous polyposis coli interaction

Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae

The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro

Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

Structure of the rgRGS domain of p115RhoGEF

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10.1074/JBC.M105274200

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