Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. - Wikidata - awgldk - TriplyDB

Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells.

Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells.

http://www.wikidata.org/entity/Q43792226

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Macrocyclic histone deacetylase inhibitors Targeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implications Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy Aberrant histone acetylation promotes mitochondrial respiratory suppression in the brain of alcoholic rats.The G1 phase arrest and apoptosis by intrinsic pathway induced by valproic acid inhibit proliferation of BGC-823 gastric carcinoma cells.Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.Histone deacetylases 9 and 10 are required for homologous recombination.Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells.Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.Histone deacetylase inhibitors in clinical development.Lead Induces Apoptosis and Histone Hyperacetylation in Rat Cardiovascular Tissues.Histone deacetylase inhibitors induce apoptosis in both Type I and Type II endometrial cancer cells.Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin Histone deacetylase inhibitors: insights into mechanisms of lethality.Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases.Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells.Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.HDAC inhibitors in HIV.Natural products as zinc-dependent histone deacetylase inhibitors.HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters (Review)Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.Histone Deacetylase Inhibitors as Anticancer Drugs.Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo.Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells.Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1.Immunohistochemical analysis of acetylation, proliferation, mitosis, and apoptosis in tumor xenografts following administration of a histone deacetylase inhibitor--a pilot study.Histone deacetylase inhibitor NVP-LAQ824 has significant activity against myeloid leukemia cells in vitro and in vivo.FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells.p53-independent induction of p21(waf1/cip1) contributes to the activation of caspases in GTP-depletion-induced apoptosis of insulin-secreting cells.Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation.Histone Deacetylase Inhibitor SAHA as Potential Targeted Therapy Agent for Larynx Cancer Cells Regulation of autophagy by ceramide-CD95-PERK signaling.The in vitro apoptotic effects of A248 and A1659, newly synthetic histone deacetylase inhibitors in oral cancer cells.Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors.Apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive human leukaemia cells by enhancing the activation of mitochondria-dependent caspase cascades.

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P2860

Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells.

http://www.wikidata.org/entity/Q43792226

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

@zh-my

2001年学术文章

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2001年學術文章

@yue

2001年學術文章

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name

Apicidin, a histone deacetylas ...... promyelocytic leukemia cells.

@en

Apicidin, a histone deacetylas ...... promyelocytic leukemia cells.

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type

label

Apicidin, a histone deacetylas ...... promyelocytic leukemia cells.

@en

Apicidin, a histone deacetylas ...... promyelocytic leukemia cells.

@nl

prefLabel

Apicidin, a histone deacetylas ...... promyelocytic leukemia cells.

@en

Apicidin, a histone deacetylas ...... promyelocytic leukemia cells.

@nl

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P1433

Journal of Biological Chemistry

P1476

Apicidin, a histone deacetylas ...... promyelocytic leukemia cells.

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P2093

Gyu-Un Bae

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Hoi Young Lee

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Hyang-Woo Lee

http://www.w3.org/2001/XMLSchema#string

Jeung-Whan Han

http://www.w3.org/2001/XMLSchema#string

Jong Woo Yoon

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Seong Hoon Ahn

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So Hee Kwon

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Sungyoul Hong

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Yin-Won Lee

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Yong Kee Kim

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P2860

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Histone acetylation in chromatin structure and transcription

What's up and down with histone deacetylation and transcription?

Characterization of Fas (Apo-1, CD95)-Fas ligand interaction

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway

P304

2073-2080

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P356

10.1074/JBC.M106699200

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P433

3

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P478

277

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11698395

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