Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells.
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The proximal signaling network of the BCR-ABL1 oncogene shows a modular organizationIdentification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesisCarboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesisThe Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapyClarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF1.MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addictionFrom Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and BeyondAbnormal hematopoiesis in Gab2 mutant miceStat5 as a diagnostic marker for leukemia.Molecular biology of bcr-abl1-positive chronic myeloid leukemia.In Vitro Apoptotic Effects of Farnesyltransferase blockade in Acute Myeloid Leukemia Cells.Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity.The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.The influence of STAT5 antisense oligonucleotides on the proliferation and apoptosis of selected human leukaemic cell lines.Chronic myelogenous leukaemia exosomes modulate bone marrow microenvironment through activation of epidermal growth factor receptor.Adiponectin enhances Imatinib anti-tumour activity in human chronic myeloid leukaemia cells with serum levels associated with Imatinib efficacy in early chronic phase patients.Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism.Activated Ca2+/calmodulin-dependent protein kinase IIgamma is a critical regulator of myeloid leukemia cell proliferation.PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cellsIdentification of transcriptional targets associated with the expression of p210 Bcr-Abl.Overexpression of cyclin D1 in accelerated-phase chronic myeloid leukemia.A Bcr/Abl-independent, Lyn-dependent form of imatinib mesylate (STI-571) resistance is associated with altered expression of Bcl-2.Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit.Drug target optimization in chronic myeloid leukemia using innovative computational platform.Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells.Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development.BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.Altered intracellular signaling by imatinib increases the anti-cancer effects of tyrosine kinase inhibitors in chronic myelogenous leukemia cells.Research on the epigenetic regulation mechanism of the PTPN6 gene in advanced chronic myeloid leukaemia.
P2860
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P2860
Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Functional cooperation among R ...... ties of BCR/ABL in K562 cells.
@en
Functional cooperation among R ...... ties of BCR/ABL in K562 cells.
@nl
type
label
Functional cooperation among R ...... ties of BCR/ABL in K562 cells.
@en
Functional cooperation among R ...... ties of BCR/ABL in K562 cells.
@nl
prefLabel
Functional cooperation among R ...... ties of BCR/ABL in K562 cells.
@en
Functional cooperation among R ...... ties of BCR/ABL in K562 cells.
@nl
P2093
P2860
P356
P1476
Functional cooperation among R ...... ties of BCR/ABL in K562 cells.
@en
P2093
Hiroshi Wakao
Itaru Matsumura
Junko Sonoyama
Masao Mizuki
Sachiko Ezoe
Takashi Machii
Xian Zhang
Yoshihisa Kataoka
Yusuke Satoh
P2860
P304
P356
10.1074/JBC.M111501200
P407
P577
2002-01-04T00:00:00Z