Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating.

Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating.

Item
http://www.wikidata.org/entity/Q43852907
Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.The H-loop in the second nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator is required for efficient chloride channel closingADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function inChimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTRAdenylate kinase activity in ABC transporters.Reversible silencing of CFTR chloride channels by glutathionylation.A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.State-dependent modulation of CFTR gating by pyrophosphate.Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC.Structural mechanisms of CFTR function and dysfunction.Proteomic analysis of the airway surface liquid: modulation by proinflammatory cytokines
P2860

Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating.

Item
http://www.wikidata.org/entity/Q43852907
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Mutations that change the posi ...... of CFTR alter channel gating.
@en
Mutations that change the posi ...... of CFTR alter channel gating.
@nl
type
label
Mutations that change the posi ...... of CFTR alter channel gating.
@en
Mutations that change the posi ...... of CFTR alter channel gating.
@nl
prefLabel
Mutations that change the posi ...... of CFTR alter channel gating.
@en
Mutations that change the posi ...... of CFTR alter channel gating.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Mutations that change the posi ...... of CFTR alter channel gating.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698