Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates.
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Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinasesBasis for the specificity and activation of the serpin protein Z-dependent proteinase inhibitor (ZPI) as an inhibitor of membrane-associated factor XaEngineering the substrate and inhibitor specificities of human coagulation Factor VIIaCombinatorial Enzyme Design Probes Allostery and Cooperativity in the Trypsin FoldExosite-driven substrate specificity and function in coagulationApproaches to selective peptidic inhibitors of factor Xa.Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrateFactor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites.The extended cleavage specificity of human thrombin.An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3.Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.Determinants of the specificity of protease-activated receptors 1 and 2 signaling by factor Xa and thrombinSequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function.Quantitative functional analysis of protein complexes on surfaces.Factor Xa active site substrate specificity with substrate phage display and computational molecular modeling.Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitisThe transition of prothrombin to thrombin.Molecular dynamics simulations of Factor Xa: insight into conformational transition of its binding subsites.Exosite determinants of serpin specificity.Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases.Recurrence of a Phe31Ser mutation in the Gla domain of blood coagulation factor X, in unrelated Algerian families: a founder effect?An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII.Engineering functional antithrombin exosites in alpha1-proteinase inhibitor that specifically promote the inhibition of factor Xa and factor IXa.The contribution of amino acid region ASP695-TYR698 of factor V to procofactor activation and factor Va function.Specificity and reactive loop length requirements for crmA inhibition of serine proteases.Amino acids Glu323, Tyr324, Glu330, and Val331 of factor Va heavy chain are essential for expression of cofactor activity.Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas.The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions.PoPS: a computational tool for modeling and predicting protease specificity.Determination of protease subsite preference on SPOT peptide array by fluorescence quenching-based assay.
P2860
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P2860
Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Mapping of the catalytic groov ...... its macromolecule substrates.
@en
Mapping of the catalytic groov ...... its macromolecule substrates.
@nl
type
label
Mapping of the catalytic groov ...... its macromolecule substrates.
@en
Mapping of the catalytic groov ...... its macromolecule substrates.
@nl
prefLabel
Mapping of the catalytic groov ...... its macromolecule substrates.
@en
Mapping of the catalytic groov ...... its macromolecule substrates.
@nl
P2093
P2860
P356
P1476
Mapping of the catalytic groov ...... r its macromolecule substrates
@en
P2093
Luiz Juliano
Maria A Juliano
Pierre-Emmanuel Marque
Virginie B Louvain
P2860
P304
20527-20534
P356
10.1074/JBC.M201139200
P407
P577
2002-03-29T00:00:00Z