Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
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KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancerA cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infectionComputational identification of uncharacterized cruzain binding sitesIdentification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPBStructural and antitrypanosomal data of different carbasones of piperitone.Identification of a new class of nonpeptidic inhibitors of cruzain.Two approaches to discovering and developing new drugs for Chagas disease.Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L.Screening of Potential anti-Trypanosoma cruzi Candidates: In Vitro and In Vivo Studies.Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenellaSynthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.Crystal structure of [(E)-({2-[3-(2-{(1E)-[(carbamo-thioyl-amino)-imino]-meth-yl}phen-oxy)prop-oxy]phen-yl}methyl-idene)amino]-thio-urea with an unknown solvateNovel antitrypanosomal agents.Drug discovery and development for neglected parasitic diseases.Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.A role for the root cap in root branching revealed by the non-auxin probe naxillin.Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.Microwave assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones.Trypanocidal drugs: mechanisms, resistance and new targets.2-Cyclo-heptyl-idene-N-phenyl-hydrazine-carbo-thio-amide.Looking at the proteases from a simple perspective.Recent advances in the therapeutic applications of pyrazolines.Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes.Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatBSynthesis, X-ray crystal structure, DNA binding, antioxidant and cytotoxicity studies of Ni(ii) and Pd(ii) thiosemicarbazone complexes.In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(II)-arene complexes.Antimalarial activity of thiosemicarbazones and purine derived nitriles.Synthesis, spectroscopic, and antimicrobial studies on bivalent zinc and mercury complexes of 2-formylpyridine thiosemicarbazone.Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi.Optimization of peptidyl allyl sulfones as clan CA cysteine protease inhibitors.(E)-4-[(2-carbamoylhydrazinylidene)methyl]-3-hydroxy-5-hydroxymethyl-2-methylpyridin-1-ium nitrate.Synthesis of a new series of angiotensin II receptor antagonists and antibacterial agents.5-Nitroisatin-derived thiosemicarbazones: potential antileishmanial agents.Development of Predictive QSAR Models of 4-Thiazolidinones Antitrypanosomal Activity using Modern Machine Learning Algorithms.Synthesis of novel highly functionalized 4-thiazolidinone derivatives from 4-phenyl-3-thiosemicarbazones.Leishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution.Synthesis and antimicrobial studies of novel 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one 4'-phenylthiosemicarbazones.Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study.The interplay of solvation, molecular conformation and supramolecular assembly in 1,1'-({[(ethane-1,2-diyl)dioxy](1,2-phenylene)}bis(methanylylidene))bis(thiosemicarbazide) and its N,N-dimethylformamide disolvate.
P2860
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P2860
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Synthesis and structure-activi ...... mal cysteine protease cruzain.
@en
Synthesis and structure-activi ...... mal cysteine protease cruzain.
@nl
type
label
Synthesis and structure-activi ...... mal cysteine protease cruzain.
@en
Synthesis and structure-activi ...... mal cysteine protease cruzain.
@nl
prefLabel
Synthesis and structure-activi ...... mal cysteine protease cruzain.
@en
Synthesis and structure-activi ...... mal cysteine protease cruzain.
@nl
P2093
P356
P1476
Synthesis and structure-activi ...... mal cysteine protease cruzain.
@en
P2093
Conor R Caffrey
Elizabeth Hansell
Patricia S Doyle
Tod P Holler
Xiaohui Du
P304
P356
10.1021/JM010459J
P407
P577
2002-06-01T00:00:00Z