Identification of a new class of nonpeptidic inhibitors of cruzain.
about
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsKinases as druggable targets in trypanosomatid protozoan parasitesNovel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteasesIdentification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatBNonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease ChemotherapyComplementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsUtilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia pestis Outer Protein H (YopH) Phosphatase ‡Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interferenceTwo approaches to discovering and developing new drugs for Chagas disease.Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probesParasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent.Emerging principles in protease-based drug discovery.Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges.Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment methodHost-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix.Synthesis of alpha-tetrasubstituted triazoles by copper-catalyzed silyl deprotection/azide cycloaddition.New approaches for dissecting protease functions to improve probe development and drug discoverySynthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.Coadministration of cruzipain and GM-CSF DNAs, a new immunotherapeutic vaccine against Trypanosoma cruzi infection.Looking at the proteases from a simple perspective.Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry.Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' diseaseDivergent modes of enzyme inhibition in a homologous structure-activity series.Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi.Optimization of peptidyl allyl sulfones as clan CA cysteine protease inhibitors.Asymmetric synthesis of amines using tert-butanesulfinamide.A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information.Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics.Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor.Rational Selection of Anti-Microbial Drug Targets: Unique or Conserved?Identification of levothyroxine antichagasic activity through computer-aided drug repurposing
P2860
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P2860
Identification of a new class of nonpeptidic inhibitors of cruzain.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Identification of a new class of nonpeptidic inhibitors of cruzain.
@ast
Identification of a new class of nonpeptidic inhibitors of cruzain.
@en
Identification of a new class of nonpeptidic inhibitors of cruzain.
@nl
type
label
Identification of a new class of nonpeptidic inhibitors of cruzain.
@ast
Identification of a new class of nonpeptidic inhibitors of cruzain.
@en
Identification of a new class of nonpeptidic inhibitors of cruzain.
@nl
prefLabel
Identification of a new class of nonpeptidic inhibitors of cruzain.
@ast
Identification of a new class of nonpeptidic inhibitors of cruzain.
@en
Identification of a new class of nonpeptidic inhibitors of cruzain.
@nl
P2093
P2860
P356
P1476
Identification of a new class of nonpeptidic inhibitors of cruzain.
@en
P2093
Jonathan A Ellman
Katrien Brak
Patricia S Doyle
P2860
P304
P356
10.1021/JA710254M
P407
P577
2008-04-25T00:00:00Z