Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.
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Protein C anticoagulant and cytoprotective pathwaysExosite-driven substrate specificity and function in coagulationActivated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impactActivated protein C action in inflammationRegulation of the protein C anticoagulant and antiinflammatory pathways.Inhibition of thrombin formation by active site mutated (S360A) activated protein C.Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein CMolecular recognition in the protein C anticoagulant pathway.Protective effects of non-anticoagulant activated protein C variant (D36A/L38D/A39V) in a murine model of ischaemic stroke.A thrombin-cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C.An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents.Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic strokeCytoprotective protein C pathways and implications for stroke and neurological disordersZymogenic and enzymatic properties of the 70-80 loop mutants of factor X/XaExosite-mediated substrate recognition of factor IX by factor XIa. The factor XIa heavy chain is required for initial recognition of factor IX.Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIaExosites in the substrate specificity of blood coagulation reactions.An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1Activation-resistant homozygous protein C R229W mutation causing familial perinatal intracranial hemorrhage and delayed onset of thrombosis.Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity.Neuroprotective activities of activated protein C mutant with reduced anticoagulant activityHyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.Growing insights into the potential benefits and risks of activated protein C administration in sepsis: a review of preclinical and clinical studies.Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cellsActivated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats.Down-regulation of the clotting cascade by the protein C pathway2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C.Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1.Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties.Function of the activated protein C (APC) autolysis loop in activated FVIII inactivation.Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa.Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.Importance of protein S and phospholipid for activated protein C-mediated cleavages in factor Va.Active site-independent recognition of substrates and product by bovine prothrombinase: a fluorescence resonance energy transfer study.Factor Va residues 311-325 represent an activated protein C binding region.PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.Regulation of immune cell signaling by activated protein C.Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin.
P2860
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P2860
Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Molecular characterization of ...... xosite of activated protein C.
@en
Molecular characterization of ...... xosite of activated protein C.
@nl
type
label
Molecular characterization of ...... xosite of activated protein C.
@en
Molecular characterization of ...... xosite of activated protein C.
@nl
prefLabel
Molecular characterization of ...... xosite of activated protein C.
@en
Molecular characterization of ...... xosite of activated protein C.
@nl
P2093
P2860
P356
P1476
Molecular characterization of ...... xosite of activated protein C.
@en
P2093
Alexander Tsavaler
Andrew J Gale
John H Griffin
P2860
P304
28836-28840
P356
10.1074/JBC.M204363200
P407
P577
2002-06-12T00:00:00Z