Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.
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Structural determinants of drugs acting on the Nav1.8 channelMolecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of actionThe hitchhiker's guide to the voltage-gated sodium channel galaxyNa+ channel function, regulation, structure, trafficking and sequestrationCrystal structure of a voltage-gated sodium channel in two potentially inactivated statesStructural Basis for Pharmacology of Voltage-Gated Sodium and Calcium ChannelsStructure and function of voltage-gated sodium channels at atomic resolution.Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenograftsSynthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockersLigand-based design and synthesis of novel sodium channel blockers from a combined phenytoin-lidocaine pharmacophoreAnalysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss.Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channelsIn silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices.Tryptophan substitution of a putative D4S6 gating hinge alters slow inactivation in cardiac sodium channels.Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsVoltage-gated sodium channels at 60: structure, function and pathophysiology.Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs.Analysis of the action of lidocaine on insect sodium channels.Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channelIon channel pharmacology.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Hinge-bending motions in the pore domain of a bacterial voltage-gated sodium channelEvaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents.Sodium channel inactivation: molecular determinants and modulation.Compound-specific effects of mutations at Val787 in DII-S6 of Nav 1.4 sodium channels on the action of sodium channel inhibitor insecticides.Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analoguesBlock of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway.State-dependent block of wild-type and inactivation-deficient Na+ channels by flecainide.Investigating the putative glycine hinge in Shaker potassium channel.Lidocaine-induced Brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel.Voltage-gated sodium channel blockers for the treatment of neuropathic pain.Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel.The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channelUsing lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticidesNovel molecular determinants in the pore region of sodium channels regulate local anesthetic binding.
P2860
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P2860
Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Role of amino acid residues in ...... pendent gating and drug block.
@en
Role of amino acid residues in ...... pendent gating and drug block.
@nl
type
label
Role of amino acid residues in ...... pendent gating and drug block.
@en
Role of amino acid residues in ...... pendent gating and drug block.
@nl
prefLabel
Role of amino acid residues in ...... pendent gating and drug block.
@en
Role of amino acid residues in ...... pendent gating and drug block.
@nl
P2093
P2860
P356
P1476
Role of amino acid residues in ...... ependent gating and drug block
@en
P2093
Caroline Pate
Diane Idsvoog
Jancy C McPhee
Todd Scheuer
William A Catterall
P2860
P304
35393-35401
P356
10.1074/JBC.M206126200
P407
P577
2002-07-18T00:00:00Z