The Glu-84 of the ParC subunit plays critical roles in both topoisomerase IV-quinolone and topoisomerase IV-DNA interactions.
about
Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.Replacement of ParC alpha4 helix with that of GyrA increases the stability and cytotoxicity of topoisomerase IV-quinolone-DNA ternary complexes.Mechanisms of drug resistance: quinolone resistance.Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.Quinolone-mediated bacterial death.Quinolone resistance due to reduced target enzyme expressionThe pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus.Effects of magnesium and related divalent metal ions in topoisomerase structure and function.Mechanism of quinolone action and resistance.Selective inhibition of bacterial and human topoisomerases by N-arylacyl O-sulfonated aminoglycoside derivatives.Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance.Mutations in topoisomerase genes of fluoroquinolone-resistant salmonellae in Hong Kong.Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of actionHot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases.Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.Staphylococcus aureus gyrase-quinolone-DNA ternary complexes fail to arrest replication fork progression in vitro. Effects of salt on the DNA binding mode and the catalytic activity of S. aureus gyrase.Double-Serine Fluoroquinolone Resistance Mutations Advance Major International Clones and Lineages of Various Multi-Drug Resistant Bacteria.Mechanism of action of and resistance to quinolones
P2860
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P2860
The Glu-84 of the ParC subunit plays critical roles in both topoisomerase IV-quinolone and topoisomerase IV-DNA interactions.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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2002年學術文章
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name
The Glu-84 of the ParC subunit ...... isomerase IV-DNA interactions.
@en
The Glu-84 of the ParC subunit ...... isomerase IV-DNA interactions.
@nl
type
label
The Glu-84 of the ParC subunit ...... isomerase IV-DNA interactions.
@en
The Glu-84 of the ParC subunit ...... isomerase IV-DNA interactions.
@nl
prefLabel
The Glu-84 of the ParC subunit ...... isomerase IV-DNA interactions.
@en
The Glu-84 of the ParC subunit ...... isomerase IV-DNA interactions.
@nl
P356
P1433
P1476
The Glu-84 of the ParC subunit ...... isomerase IV-DNA interactions.
@en
P2093
Hiroshi Hiasa
P304
11779-11785
P356
10.1021/BI026352V
P407
P577
2002-10-01T00:00:00Z