The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice. - Wikidata - awgldk - TriplyDB

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.

http://www.wikidata.org/entity/Q44196383

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Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver The role of bile salts in liver regeneration Bile acid signaling in metabolic disease and drug therapy Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5 Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands Bile acid flux is necessary for normal liver regeneration.Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer.Bile acid signaling and liver regeneration.Non alcoholic steatohepatitis a precursor for hepatocellular carcinoma development.Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients Simultaneous bile duct and portal vein ligation induces faster atrophy/hypertrophy complex than portal vein ligation: role of bile acids.TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation Implications of microbiota and bile acid in liver injury and regeneration.Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARα(PAC) mice due to dysregulated bile acid synthesis Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration.Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice.Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study.Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration.Up-regulated extracellular matrix components and inflammatory chemokines may impair the regeneration of cholestatic liver Therapeutic targets for cholestatic liver injury A synthetic biology-based device prevents liver injury in mice The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5.TGR5, Not Only a Metabolic Regulator.Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency.The bile acid TGR5 membrane receptor: from basic research to clinical application.TGR5 in inflammation and cardiovascular disease.Emerging drugs for the treatment of Primary Biliary Cholangitis.TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.New therapeutic concepts in bile acid transport and signaling for management of cholestasis.Hepatostat: Liver regeneration and normal liver tissue maintenance.Bile acids and bariatric surgery.Update on the Mechanisms of Liver Regeneration.Mechanisms of bile acid mediated inflammation in the liver.The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis.Glucagon-Like Peptide-2 Alters Bile Acid Metabolism in Parenteral Nutrition--Associated Liver Disease.Cholesterol attenuates cytoprotective effects of phosphatidylcholine against bile salts.Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signaling pathways in mice.Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells.

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The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice.

http://www.wikidata.org/entity/Q44196383

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Anne Spraul

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Aurore Besnard

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Bingkaï Liu

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Boris Julien

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Dominique Rainteau

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Isabelle Doignon

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Isabelle Garcin

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Kristina Schoonjans

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Lydie Humbert

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Noémie Péan

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P2860

Identification of membrane-type receptor for bile acids (M-BAR)

A G protein-coupled receptor responsive to bile acids

The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells

Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.

Liver regeneration: from myth to mechanism.

The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling

Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.

Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice.

The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice

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1451-1460

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10.1002/HEP.26463

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4

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58

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Catherine Guettier

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236921057

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23686672

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