Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice.
about
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonistsAllostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesOpioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesicsOpioid receptor trafficking and interaction in nociceptorsAntibodies to probe endogenous G protein-coupled receptor heteromer expression, regulation, and functionOpioid receptors: toward separation of analgesic from undesirable effectsOpioid receptor heteromers in analgesiaReceptor heteromerization expands the repertoire of cannabinoid signaling in rodent neuronsCurrent research on opioid receptor function.Heterodimerization of mu and delta opioid receptors: A role in opiate synergyMu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cellsAnti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonismCholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cellsDevelopmental expression of δ-opioid receptors during maturation of the parasympathetic, sympathetic, and sensory innervations of the neonatal heart: early targets for opioid regulation of autonomic controlReceptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimersA Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of and Opioid Receptor Hetero-oligomersCross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 NeuronsAdenylyl cyclase type 5 (AC5) is an essential mediator of morphine action.An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-AmericansAgonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization.Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid PharmacophoreBi- or multifunctional opioid peptide drugs.Search for the "ideal analgesic" in pain treatment by engineering the mu-opioid receptor.Emergence of functional spinal delta opioid receptors after chronic ethanol exposureFunctional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene.The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects.Intrathecal delivery of a mutant micro-opioid receptor activated by naloxone as a possible antinociceptive paradigm.How to design an opioid drug that causes reduced tolerance and dependence.Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway.Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat.Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects.Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand seriesModulation of pain transmission by G-protein-coupled receptors.Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity.Recent advances in the use of opioids for cancer painRevolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.
P2860
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P2860
Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Retention of supraspinal delta ...... opioid receptor knockout mice.
@en
Retention of supraspinal delta ...... opioid receptor knockout mice.
@nl
type
label
Retention of supraspinal delta ...... opioid receptor knockout mice.
@en
Retention of supraspinal delta ...... opioid receptor knockout mice.
@nl
prefLabel
Retention of supraspinal delta ...... opioid receptor knockout mice.
@en
Retention of supraspinal delta ...... opioid receptor knockout mice.
@nl
P2093
P1433
P1476
Retention of supraspinal delta ...... opioid receptor knockout mice.
@en
P2093
Nitsche JF
Pasternak GW
Schuller AG
Unterwald E
P304
P356
10.1016/S0896-6273(00)80836-3
P407
P577
1999-09-01T00:00:00Z