Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation.
about
Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neuronsEngineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signalingOpioid receptor trafficking and interaction in nociceptorsMembrane glycoprotein M6a interacts with the micro-opioid receptor and facilitates receptor endocytosis and recyclingRole of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization.Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D(2) receptors.Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activationOpioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1.Opioid receptor desensitization: mechanisms and its link to toleranceCholesterol regulates micro-opioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts.Post-transcriptional regulation of opioid receptors in the nervous system.Fast modulation of μ-opioid receptor (MOR) recycling is mediated by receptor agonists.Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.Why is delta endocytosis required for effective activation of notch?Ubiquitination of G protein-coupled receptors: functional implications and drug discovery.Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Agonist-selective signaling is determined by the receptor location within the membrane domains.Arrestin-dependent but G-protein coupled receptor kinase-independent uncoupling of D2-dopamine receptors.Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestinsFunctional characterization of human variants of the mu-opioid receptor geneAnalgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery.Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors.Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia.Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain.Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.Phosphorylation state of mu-opioid receptor determines the alternative recycling of receptor via Rab4 or Rab11 pathwaySrc promotes delta opioid receptor (DOR) desensitization by interfering with receptor recycling.Phosphorylation of the delta-opioid receptor regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization.p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR.Ligand-specific regulation of the endogenous mu-opioid receptor by chronic treatment with mu-opioid peptide agonistsChemical genetic engineering of G protein-coupled receptor kinase 2.Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo.
P2860
Q21131252-881E7586-155F-4B32-AE6D-834DF2DBC353Q24658250-1173FACE-DF94-4B82-80D0-84617BF7B8E6Q24797337-612F43BF-24C3-4EF7-8DDA-10768C257DD9Q26822251-2CE76B01-4E95-439F-A06A-26CCF15C5290Q28564599-56E49BDA-CD32-4ADA-A480-80F054CAA069Q33568279-2BEF38B4-8A0D-47FB-9925-E482062C9FF2Q33735970-A12E2654-F5CD-4DC1-A56B-0EB393682022Q34551407-A27E1707-BD33-41EC-97E7-93176DD555DCQ34624142-7DD184CC-A2BA-4467-A36E-526814811703Q34671312-DA0EC39D-676B-4AFF-90C7-CD2F5F197BF7Q34729984-318821C3-C74F-45BC-99A5-CDCD720E9E5EQ35080516-EC00B170-A66D-4AF4-B9ED-E0FD729B60E0Q35672802-6FEC83F9-78B3-4DAC-A423-0314DA065253Q35922445-365F45B1-1291-4802-9A72-142E4AAFED01Q36025329-B1E8DDA4-AF76-410E-B2D1-007A1D9B28EAQ36175842-16AC1766-072C-43C7-90CA-98361AA2ACE8Q36294416-807C9968-B1FE-4222-A018-6B2ABC05A3A7Q36591603-EE2596F1-319B-4FEE-A508-F7B6869CAC20Q36756874-2578BF5A-965F-4380-B4C0-0ECE4508FE73Q36779793-65510255-5232-4999-BA70-5265A560265AQ36984756-C76E2373-97AE-43D2-9309-7D4D4EF77D8CQ37249905-2E935442-5F3F-4E81-A04E-A3A56BF204DEQ37532600-D063944C-CFA4-4FDE-8DFA-35943477829FQ37630378-BE0D606C-B9D6-41ED-9E70-18F8390FAF28Q37730688-8875C000-03A9-4335-B860-E443B4BDC0F9Q38167644-F134FFB4-601D-4C3A-8D2E-E67231FDECF3Q39832239-52DA0C1E-86B9-4872-8B3F-08E0CB01E75AQ39912845-97B2A09D-429F-4EB9-A1A7-FF0FF3E2C4D5Q39972706-27EF6FD9-10CE-4540-9FDA-26F1638B4E48Q39998920-5E5846B5-AE34-4B76-A517-45E32FD77FC7Q40120465-493042DF-1F0B-4255-BE34-56D1CE90EAA7Q42086290-AB0C2B7F-580B-4975-B1BB-F9E99175306FQ42148785-39C944F8-F0F9-4784-9504-E6A41E580F61Q42825684-0426405B-6694-4CC8-8BC7-2EBA93092107Q46617034-03CA0587-473F-47AF-8C79-A4CD3A5E0426Q51145621-2BB65475-D38E-4CAF-8294-FA5E4850A949
P2860
Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Mu-opioid receptor desensitiza ...... alization, and representation.
@en
Mu-opioid receptor desensitiza ...... alization, and representation.
@nl
type
label
Mu-opioid receptor desensitiza ...... alization, and representation.
@en
Mu-opioid receptor desensitiza ...... alization, and representation.
@nl
prefLabel
Mu-opioid receptor desensitiza ...... alization, and representation.
@en
Mu-opioid receptor desensitiza ...... alization, and representation.
@nl
P2860
P356
P1476
Mu-opioid receptor desensitiza ...... alization, and representation.
@en
P2093
P2860
P304
36733-36739
P356
10.1074/JBC.M305857200
P407
P50
P577
2003-07-14T00:00:00Z