Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. - Wikidata - awgldk - TriplyDB

Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.

Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.

http://www.wikidata.org/entity/Q44511146

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Multiple system atrophy: a clinical and neuropathological perspective Exploring the accessible conformations of N-terminal acetylated α-synuclein C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.Alpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats.Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen.Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons.Peroxynitrite-induced nitrative and oxidative modifications alter tau filament formation.Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers.Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?Nitration of tau protein is linked to neurodegeneration in tauopathies Use of proteomics for the identification of novel drug targets in brain diseases.Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease Novel therapeutic strategies for the treatment of protein-misfolding diseases.Redox imbalance in Parkinson's disease.Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention Targeting the progression of Parkinson's disease.A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle.Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson's Disease?Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn).Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells.Oxidative stress promotes uptake, accumulation, and oligomerization of extracellular α-synuclein in oligodendrocytes.Cell Biology and Pathophysiology of α-Synuclein.A novel molecular mechanism for nitrated {alpha}-synuclein-induced cell death.Membrane lipid modification by docosahexaenoic acid (DHA) promotes the formation of α-synuclein inclusion bodies immunopositive for SUMO-1 in oligodendroglial cells after oxidative stress.Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells.Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence.Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide.Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity.Peroxidative aggregation of alpha-synuclein requires tyrosines

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Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications.

http://www.wikidata.org/entity/Q44511146

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年学术文章

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2003年學術文章

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2003年學術文章

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2003年學術文章

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name

Effects of oxidative and nitra ...... isms of protein modifications.

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Effects of oxidative and nitra ...... isms of protein modifications.

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type

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Effects of oxidative and nitra ...... isms of protein modifications.

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Effects of oxidative and nitra ...... isms of protein modifications.

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prefLabel

Effects of oxidative and nitra ...... isms of protein modifications.

@en

Effects of oxidative and nitra ...... isms of protein modifications.

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Journal of Biological Chemistry

P1476

Effects of oxidative and nitra ...... isms of protein modifications.

@en

P2093

Benoit I Giasson

http://www.w3.org/2001/XMLSchema#string

Erin H Norris

http://www.w3.org/2001/XMLSchema#string

Harry Ischiropoulos

http://www.w3.org/2001/XMLSchema#string

Virginia M-Y Lee

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P2860

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Alpha-synuclein in Lewy bodies

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

Widespread alterations of alpha-synuclein in multiple system atrophy

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.

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27230-27240

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scholarly article

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10.1074/JBC.M212436200

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29

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278

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2003-05-08T00:00:00Z

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