Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle.
about
A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase geneThe role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic controlBile acids: regulation of synthesisBile acid receptors and nonalcoholic fatty liver diseaseBile acid metabolism and signalingFXR signaling in the enterohepatic systemBile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rateInsights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligandsBile acid nuclear receptor FXR and digestive system diseasesFarnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasisThe farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in miceFarnesoid X receptor is essential for normal glucose homeostasisCoordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 DiabetesBile acid receptor agonist GW4064 regulates PPARγ coactivator-1α expression through estrogen receptor-related receptor αCharacterization of cardiovascular outcomes in a type 2 diabetes glucose supply and insulin demand modelBile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice.Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitusNutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome.Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene.Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.Linking epigenetics to lipid metabolism: focus on histone deacetylases.Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ miceEndocrine functions of bile acids.Deciphering the nuclear bile acid receptor FXR paradigm.Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.Distinct metabolomic signatures are associated with longevity in humans.Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expressionBile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2.FXR: a target for cholestatic syndromes?Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissueOstalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver.FXR signaling in metabolic disease.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1alpha).Endocrine and paracrine role of bile acidsBile acids as regulatory molecules.
P2860
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P2860
Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Coordinated control of cholest ...... ed to the fasted-to-fed cycle.
@en
Coordinated control of cholest ...... ed to the fasted-to-fed cycle.
@nl
type
label
Coordinated control of cholest ...... ed to the fasted-to-fed cycle.
@en
Coordinated control of cholest ...... ed to the fasted-to-fed cycle.
@nl
prefLabel
Coordinated control of cholest ...... ed to the fasted-to-fed cycle.
@en
Coordinated control of cholest ...... ed to the fasted-to-fed cycle.
@nl
P2093
P2860
P356
P1476
Coordinated control of cholest ...... ed to the fasted-to-fed cycle.
@en
P2093
Donatella Caruso
Federica Gilardi
Giovanni Galli
Maurizio Crestani
Nico Mitro
P2860
P304
39124-39132
P356
10.1074/JBC.M305079200
P407
P577
2003-07-15T00:00:00Z