Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
about
Three decades of beta-lactamase inhibitorsInhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1Strategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONEDesign, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 CarbapenemaseLigand-Dependent Disorder of the Loop Observed in Extended-Spectrum SHV-Type -LactamaseCrystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamaseDesign and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-LactamaseThe Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase VariantsCan Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis -Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of -Lactam- -Lactamase Inhibitor CombinationsPenam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and CompositionInsight into the effect of inhibitor resistant S130G mutant on physico-chemical properties of SHV type beta-lactamase: a molecular dynamics studyTazobactam inactivation of SHV-1 and the inhibitor-resistant Ser130 -->Gly SHV-1 beta-lactamase: insights into the mechanism of inhibition.Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.Inhibition of OXA-1 beta-lactamase by penems.Penicillin sulfone inhibitors of class D beta-lactamasesExploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamaseRole of Asp104 in the SHV beta-lactamase.Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.Avibactam and inhibitor-resistant SHV β-lactamasesBeta-lactamase inhibitors: evolving compounds for evolving resistance targets.Cephalosporin resistance among animal-associated Enterobacteria: a current perspective.The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition.Evolution of β-lactams resistance in Gram-negative bacteria in Tunisia.Reappraising the use of β-lactams to treat tuberculosis.N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam.Raman spectra of interchanging β-lactamase inhibitor intermediates on the millisecond time scale.Structural and sequence analysis of class A β-lactamases with respect to avibactam inhibition: impact of Ω-loop variations.Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase.Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.Following drug uptake and reactions inside Escherichia coli cells by Raman microspectroscopy.Importance of position 170 in the inhibition of GES-type β-lactamases by clavulanic acid.Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).
P2860
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P2860
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Understanding resistance to be ...... om the mutagenesis of SER-130.
@en
Understanding resistance to be ...... om the mutagenesis of SER-130.
@nl
type
label
Understanding resistance to be ...... om the mutagenesis of SER-130.
@en
Understanding resistance to be ...... om the mutagenesis of SER-130.
@nl
prefLabel
Understanding resistance to be ...... om the mutagenesis of SER-130.
@en
Understanding resistance to be ...... om the mutagenesis of SER-130.
@nl
P2093
P2860
P356
P1476
Understanding resistance to be ...... om the mutagenesis of SER-130.
@en
P2093
Christopher R Bethel
Kristine M Hujer
Marion S Helfand
Vernon E Anderson
P2860
P304
52724-52729
P356
10.1074/JBC.M306059200
P407
P577
2003-10-08T00:00:00Z