Alterations in the common fragile site gene Parkin in ovarian and other cancers. - Wikidata - awgldk - TriplyDB

Alterations in the common fragile site gene Parkin in ovarian and other cancers.

Alterations in the common fragile site gene Parkin in ovarian and other cancers.

http://www.wikidata.org/entity/Q44653680

about

Parkin mono-ubiquitinates Bcl-2 and regulates autophagy Parkin is recruited selectively to impaired mitochondria and promotes their autophagy Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites Plasticity of DNA replication initiation in Epstein-Barr virus episomes Metabolic, autophagic, and mitophagic activities in cancer initiation and progression Mitochondria and the autophagy-inflammation-cell death axis in organismal aging Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation YME1L degradation reduces mitochondrial proteolytic capacity during oxidative stress PMI: a ΔΨm independent pharmacological regulator of mitophagy Tumor suppressor and hepatocellular carcinoma Hotspots of large rare deletions in the human genome Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase Cancer and neurodegeneration: between the devil and the deep blue sea.Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells Discovering tumor suppressor genes through genome-wide copy number analysis.p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria.PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding Discovery of structural alterations in solid tumor oligodendroglioma by single molecule analysis.Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia.The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and Cancer Breakpoint mapping of 13 large parkin deletions/duplications reveals an exon 4 deletion and an exon 7 duplication as founder mutations.Restriction of trophic factors and nutrients induces PARKIN expression Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 cells.MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5 Genomic instability in the PARK2 locus is associated with Parkinson's disease.Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's families.Understanding multicellular function and disease with human tissue-specific networks.Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease.Association of a PARK2 Germline Variant and Epithelial Ovarian Cancer in a Southern Brazilian Population.MAVS maintains mitochondrial homeostasis via autophagy.Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids.Loss of iron triggers PINK1/Parkin-independent mitophagy.Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants.

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Alterations in the common fragile site gene Parkin in ovarian and other cancers.

http://www.wikidata.org/entity/Q44653680

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2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

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2003年学术文章

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2003年學術文章

@yue

2003年學術文章

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name

Alterations in the common fragile site gene Parkin in ovarian and other cancers.

@en

Alterations in the common fragile site gene Parkin in ovarian and other cancers.

@nl

type

label

Alterations in the common fragile site gene Parkin in ovarian and other cancers.

@en

Alterations in the common fragile site gene Parkin in ovarian and other cancers.

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prefLabel

Alterations in the common fragile site gene Parkin in ovarian and other cancers.

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Alterations in the common fragile site gene Parkin in ovarian and other cancers.

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Alterations in the common fragile site gene Parkin in ovarian and other cancers.

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Birgitt Schüle

http://www.w3.org/2001/XMLSchema#string

David I Smith

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Fang Wang

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Leslie A Phillips

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Nicole A Becker

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Norman Kock

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Stacy R Denison

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P2860

Two genetic hits (more or less) to cancer

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

Association between early-onset Parkinson's disease and mutations in the parkin gene

Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies.

Replacement of Fhit in cancer cells suppresses tumorigenicity

Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines.

Parkin is linked to the ubiquitin pathway.

Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27

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10.1038/SJ.ONC.1207072

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