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Replacement of Fhit in cancer cells suppresses tumorigenicity

Replacement of Fhit in cancer cells suppresses tumorigenicity

http://www.wikidata.org/entity/Q33726007

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The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit Fhit is a physiological target of the protein kinase Src Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8 Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9 Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding Molecular biology of lung cancer: clinical implications Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3 Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae.Common fragile sites: genomic hotspots of DNA damage and carcinogenesis Serine, glycine and one-carbon units: cancer metabolism in full circle Initiation of genome instability and preneoplastic processes through loss of Fhit expression The histidine triad protein Hint is not required for murine development or Cdk7 function Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.Novel tumor suppressor locus in human chromosome region 3p14.2.Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ Association of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs).Cloning and expression of a new cDNA from monocotyledonous plants coding for a diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from barley (Hordeum vulgare).High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis The histidine triad superfamily of nucleotide-binding proteins.Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung cancer cells.Novel endogenous type D retroviral particles expressed at high levels in a SCID mouse thymic lymphoma Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.Molecular and genetic aspects of lung cancer.Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene.Lung cancer. 9: Molecular biology of lung cancer: clinical implications.Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines.Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition.Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis.Fragile sites-cytogenetic similarity with molecular diversity.Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species.

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P2860

Replacement of Fhit in cancer cells suppresses tumorigenicity

http://www.wikidata.org/entity/Q33726007

description

1997 nî lūn-bûn

@nan

1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1997年の論文

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1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

name

Replacement of Fhit in cancer cells suppresses tumorigenicity

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Replacement of Fhit in cancer cells suppresses tumorigenicity

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type

label

Replacement of Fhit in cancer cells suppresses tumorigenicity

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Replacement of Fhit in cancer cells suppresses tumorigenicity

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prefLabel

Replacement of Fhit in cancer cells suppresses tumorigenicity

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Replacement of Fhit in cancer cells suppresses tumorigenicity

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PNAS.94.25.13771

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Replacement of Fhit in cancer cells suppresses tumorigenicity

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A Greco

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A K Robinson

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G Schwartz

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K Huebner

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L D Barnes

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L Fusetti

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P McCue

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V Eryomin

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Z Siprashvili

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P2860

Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites

Characteristics of a human cell line transformed by DNA from human adenovirus type 5

Suppression of human colorectal carcinoma cell growth by wild-type p53

The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals.

Association between cigarette smoking and FHIT gene alterations in lung cancer.

Cell surface antigens of human renal cancer defined by autologous typing.

Cloning of the Schizosaccharomyces pombe gene encoding diadenosine 5',5"'-P1,P4-tetraphosphate (Ap4A) asymmetrical hydrolase: sequence similarity with the histidine triad (HIT) protein family

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13771-13776

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10.1073/PNAS.94.25.13771

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25

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94

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Marco A. Pierotti

Gabriella Sozzi

Carlo Maria Croce

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1997-12-01T00:00:00Z

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24458948

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