Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
about
Identifying tumor cell growth inhibitors by combinatorial chemistry and zebrafish assaysGSK-3 Inhibitors: Preclinical and Clinical Focus on CNSIndirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migrationIndirubin and Indirubin Derivatives for Counteracting Proliferative DiseasesKinases as druggable targets in trypanosomatid protozoan parasitesCutaneous wound healing: recruiting developmental pathways for regenerationNeuroprotective Mechanisms Mediated by CDK5 InhibitionAdaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous systemWnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitroChemical modulation of memory formation in larval zebrafish.Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development.Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors.Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis.Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries.A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcriptionAn inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3Wnt signaling activates Shh signaling in early postnatal intervertebral discs, and re-activates Shh signaling in old discs in the mouse.Understanding the roadmaps to induced pluripotency.Effect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids.Structure-based virtual screening of glycogen synthase kinase 3β inhibitors: analysis of scoring functions applied to large true actives and decoy sets.Salivary gland gene expression atlas identifies a new regulator of branching morphogenesis.The small molecule indirubin-3'-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells.ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitorsApplication of a homogenous membrane potential assay to assess mitochondrial function.Discovery, synthesis, and in vitro evaluation of West Nile virus protease inhibitors based on the 9,10-dihydro-3H,4aH-1,3,9,10a-tetraazaphenanthren-4-one scaffold.Indirubin derivative E804 inhibits angiogenesis.Canonical Wnt/β-catenin regulation of liver receptor homolog-1 mediates pluripotency gene expressionDiscovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5/p25 inhibitors by structure-based virtual screening6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions.Cytochrome P450 Enzyme Metabolites in Lead Discovery and Development.Wnt/β-catenin controls follistatin signalling to regulate satellite cell myogenic potential.Pityriazepin and other potent AhR ligands isolated from Malassezia furfur yeastFrom Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease ModelsA novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signalingIndirubin-3'-(2,3 dihydroxypropyl)-oximether (E804) is a potent modulator of LPS-stimulated macrophage functions.Targeting glycogen synthase kinase-3 in insulin signalling.
P2860
Q21092150-D92BA6BD-1F83-4E91-A04A-784A7AED8AE9Q21129334-67E3391B-7B19-41E4-9FE7-C3D390DBDADDQ24604398-683AC5E4-C97E-4BE5-8138-E588294B32ABQ26784341-9D1EF403-F2A8-404F-8909-05FDC80ADCB4Q26786761-336ED1D9-7757-4845-900F-5E8177A7F7B2Q27004417-924CDBE6-894D-447A-99EB-123DA804C86CQ28082792-5A0C1338-999D-4C9F-8ECA-ECA0C51F198AQ28389419-7520C3EA-5F67-43EB-9F4C-EA614E8DCDD6Q28535094-1DC54163-E38D-49E9-B7B1-DC853733229AQ30474076-6E1E9F7C-B192-4B73-99F9-66D7392F9404Q30503626-316DC49A-09A8-4DDC-8399-94404B54E779Q33211084-4DB92974-1AA4-4CC3-A837-ED41DD761EFAQ33224912-DDA6F3D8-3262-40CF-AB90-842E8D626733Q33382575-EACA5C77-6052-49AA-BFCA-4BCD42175BD9Q33627310-BDC9A4F6-BF60-472D-9FEA-6C2B8ED981CAQ33688195-642F9339-4387-4700-A26C-C71C85030D20Q33706077-036F5797-4927-48F0-B130-4E53997DCEA5Q33720285-DF63767C-20D8-45CB-A894-6DA2BA24E99FQ33864513-DC757537-B48F-4ECC-9E1C-BD670B335D82Q33934472-B3FFCD76-3346-45FC-B78C-80743439FF25Q33944187-B888C3EA-7013-4B60-BC61-6258AB19DCEEQ34018084-92AC1CC1-4AE0-45FD-846A-CE0974B8B143Q34124971-FFCC23C7-2E05-4EB5-8551-BD1103ECDCD2Q34138284-D367D8E7-04F5-44A3-B254-AFD78B756062Q34202269-0AA53764-BBC8-421D-8CD9-60CF2FE0C62AQ34203882-EB159C3F-4948-4F4D-AEF1-F0137460C2F2Q34253261-6D72312D-BFD3-45D0-A99D-B40168823058Q34254864-AE8E48B3-4512-4160-A798-8F1054B4AA58Q34378505-EFC85BF5-8A71-4459-B388-D37A87F2435DQ34625383-92AD105C-E5A1-4DEE-9336-88EF459F76EDQ35022350-68F98A4C-63D9-4199-91E3-8FF844163D50Q35085912-9B32C479-982F-4443-822B-10E5E4CD4870Q35194778-896D8ED7-8A96-4A6B-8D18-B150ABD512DEQ35575301-6CAB7296-BFA7-4F62-8CF1-56F99CB917F8Q35679675-253D9D59-F238-4EE0-AF52-7469C69808E1Q35931675-45395A38-7727-4564-B967-C8C19649554DQ36128825-4A4B274E-4717-41AE-81F9-849D7C4C0837Q36384334-FE8D64BA-4647-4924-8886-3C3FF58CD9FCQ36476545-37A2A1A9-A883-4E94-AC2D-ABB867976ED8Q36481069-73C9BE49-0F96-48C2-AE91-DA0FB6B7342C
P2860
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Structural basis for the synth ...... and cyclin-dependent kinases.
@en
Structural basis for the synth ...... and cyclin-dependent kinases.
@nl
type
label
Structural basis for the synth ...... and cyclin-dependent kinases.
@en
Structural basis for the synth ...... and cyclin-dependent kinases.
@nl
prefLabel
Structural basis for the synth ...... and cyclin-dependent kinases.
@en
Structural basis for the synth ...... and cyclin-dependent kinases.
@nl
P2093
P50
P356
P1476
Structural basis for the synth ...... and cyclin-dependent kinases.
@en
P2093
Aldo Tarricone
Alexios-Leandros Skaltsounis
Laurent Meijer
Maryse Leost
Panagiotis Polychronopoulos
S Mark Roe
P304
P356
10.1021/JM031016D
P407
P50
P577
2004-02-01T00:00:00Z