Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy.
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The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian CancerProteolytic excision of a repressive loop domain in tartrate-resistant acid phosphatase by cathepsin K in osteoclastsProteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: implications for lytic enzyme transport and bone metabolism.Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development.A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.Inactivation of the cystatin E/M tumor suppressor gene in cervical cancerCathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin.Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases.Protective role of cathepsin L in mouse skin carcinogenesis.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairA Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster.Cathepsin L targeting in cancer treatment.Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in miceCathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model.Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-κB.Cathepsin L in metastatic bone disease: therapeutic implications.Current, new and future treatments of osteoporosis.Specialized roles for cysteine cathepsins in health and disease.Deciphering the functions of the hair follicle infundibulum in skin physiology and disease.Cysteine proteases in atherosclerosis.Development of a highly potent, selective, and cell-active inhibitor of cysteine cathepsin L-A hybrid design approach.Cathepsin L splice variants in human breast cell lines.An assessment of the chondroprotective effects of intra-articular application of statin and tetracycline on early-stage experimental osteoarthritis.Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein.Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese miceTerminal differentiation of chick embryo chondrocytes requires shedding of a cell surface protein that binds 1,25-dihydroxyvitamin D3.Cell type-specific functions of the lysosomal protease cathepsin L in the heart.
P2860
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P2860
Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy.
description
2004 nî lūn-bûn
@nan
2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
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2004年學術文章
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2004年學術文章
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name
Cathepsin L-deficient mice exh ...... porosis following ovariectomy.
@en
Cathepsin L-deficient mice exh ...... porosis following ovariectomy.
@nl
type
label
Cathepsin L-deficient mice exh ...... porosis following ovariectomy.
@en
Cathepsin L-deficient mice exh ...... porosis following ovariectomy.
@nl
prefLabel
Cathepsin L-deficient mice exh ...... porosis following ovariectomy.
@en
Cathepsin L-deficient mice exh ...... porosis following ovariectomy.
@nl
P2093
P2860
P1476
Cathepsin L-deficient mice exh ...... porosis following ovariectomy.
@en
P2093
Andrew Millest
Colin Martin
David Tucker
Diane Neerunjun
Fiona Harper
Gillian Slynn
Jonathan Bowyer
Rose Maciewicz
Wendy Potts
P2860
P356
10.1111/J.0959-9673.2004.00373.X
P577
2004-04-01T00:00:00Z