The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.
about
Targeting xenobiotic receptors PXR and CAR in human diseasesPhenobarbital confers its diverse effects by activating the orphan nuclear receptor carA PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrileEvolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile saltsThe cytochrome P450 (CYP) gene superfamily in Daphnia pulexIntestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists.Alterations in xenobiotic metabolism in the long-lived Little mice.Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissuesThe role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null miceBile acid signaling and liver regeneration.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesDeficiency of Capicua disrupts bile acid homeostasis.Phenytoin induction of the cyp2c37 gene is mediated by the constitutive androstane receptor.Small-molecule modulators of the constitutive androstane receptor.Nuclear receptor variants in liver disease.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Small-molecule modulators of PXR and CAR.CAR and PXR: the xenobiotic-sensing receptors.Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ miceRNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.Deciphering the roles of the constitutive androstane receptor in energy metabolism.Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice.Functional evolution of the pregnane X receptor.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics.The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation.Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in miceNuclear receptors as therapeutic targets in cholestatic liver diseases.
P2860
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P2860
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
The constitutive androstane re ...... e acid-induced hepatotoxicity.
@en
The constitutive androstane re ...... e acid-induced hepatotoxicity.
@nl
type
label
The constitutive androstane re ...... e acid-induced hepatotoxicity.
@en
The constitutive androstane re ...... e acid-induced hepatotoxicity.
@nl
prefLabel
The constitutive androstane re ...... e acid-induced hepatotoxicity.
@en
The constitutive androstane re ...... e acid-induced hepatotoxicity.
@nl
P2093
P2860
P356
P1476
The constitutive androstane re ...... e acid-induced hepatotoxicity.
@en
P2093
David D Moore
Mohammed Qatanani
Wendong Huang
P2860
P304
49517-49522
P356
10.1074/JBC.M409041200
P407
P577
2004-09-08T00:00:00Z