Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. - Wikidata - awgldk - TriplyDB

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.

http://www.wikidata.org/entity/Q45085155

about

Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1 A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5 Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65 Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b Cutting the brakes on hematopoietic regeneration by blocking TGFβ to limit chemotherapy-induced myelosuppression Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function Transcriptional Regulation of Mononuclear Phagocyte Development From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood formation Transcription factor-mediated reprogramming toward hematopoietic stem cells Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells A critical role for Apc in hematopoietic stem and progenitor cell survival Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2 Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling Adult hematopoietic stem cells require NKAP for maintenance and survival Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells Transcriptional repressor Gfi1 integrates cytokine-receptor signals controlling B-cell differentiation.Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.Minireview: Nuclear receptors, hematopoiesis, and stem cells.GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer.Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.p53 regulates hematopoietic stem cell quiescence.The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases.The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.The endoplasmic reticulum chaperone protein GRP94 is required for maintaining hematopoietic stem cell interactions with the adult bone marrow niche.Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism.CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway

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P2860

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.

http://www.wikidata.org/entity/Q45085155

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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name

Gfi-1 restricts proliferation ...... of haematopoietic stem cells.

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Gfi-1 restricts proliferation ...... of haematopoietic stem cells.

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type

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Gfi-1 restricts proliferation ...... of haematopoietic stem cells.

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Gfi-1 restricts proliferation ...... of haematopoietic stem cells.

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Gfi-1 restricts proliferation ...... of haematopoietic stem cells.

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Gfi-1 restricts proliferation ...... of haematopoietic stem cells.

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Gfi-1 restricts proliferation ...... of haematopoietic stem cells.

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P2093

Hanno Hock

http://www.w3.org/2001/XMLSchema#string

Heather M Rooke

http://www.w3.org/2001/XMLSchema#string

Jeffrey W Schindler

http://www.w3.org/2001/XMLSchema#string

Melanie J Hamblen

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Shireen Saleque

http://www.w3.org/2001/XMLSchema#string

Stuart H Orkin

http://www.w3.org/2001/XMLSchema#string

Yuko Fujiwara

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P2860

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

An early haematopoietic defect in mice lacking the transcription factor GATA-2

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

The genetic program of hematopoietic stem cells.

RTCGD: retroviral tagged cancer gene database.

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

Serial depletion and regeneration of the murine hematopoietic system. Implications for hematopoietic organization and the study of cellular aging.

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10.1038/NATURE02994

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